@inproceedings{4d77d9a604104ccdbedcd4d67221a7f7,
title = "Rapid, sensitive detection of intact SARS-CoV-2 using DNA nets and a smartphone-linked fluorimeter",
abstract = "We report a single-step, room-temperature, 5-10 minute SARS-CoV-2 saliva self-monitoring method that overcomes the limitations of existing approaches through the use of fluorophore-releasing Designer DNA Nanostructures (DDNs) that bind with the multivalent pattern of spike proteins on the exterior intact virions and an inexpensive smartphone-linked, pocket-size fluorimeter, called a “V-Pod” for its resemblance to an Apple AirPod{\texttrademark} headphone case. We characterize the V-Pod fluorimeter performance and the DDN-based assay to demonstrate a clinically relevant detection limit of 104 virus particles/mL for pseudo-typed WT SARS-CoV-2 and 105 virus particles/mL for real pathogenic variants, including Delta, Omicron, and D614g.",
keywords = "Biosensor, COVID-19 testing, Designer DNA nanostructure, Point-of-care test, Portable Fluorometer, Smartphone",
author = "Hankeun Lee and Weijing Wang and Neha Chauhan and Yanyu Xiong and Nicholas Magazine and Owen Valdescruz and Kim, {Dong Yeun} and Tianjie Qiu and Weishan Huang and Xing Wang and Cunningham, {Brian T.}",
note = "Publisher Copyright: {\textcopyright} 2023 SPIE.; Optical Diagnostics and Sensing XXIII: Toward Point-of-Care Diagnostics 2023 ; Conference date: 30-01-2023 Through 31-01-2023",
year = "2023",
doi = "10.1117/12.2650836",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Cote, {Gerard L.}",
booktitle = "Optical Diagnostics and Sensing XXIII",
address = "United States",
}