Rapid acquisition of in vivo biological images by use of optical coherence tomography

G. J. Tearney; B. E. Bouma; S. A. Boppart; B. Golubovic; E. A. Swanson; J. G. Fujimoto

doi:10.1364/OL.21.001408

Rapid acquisition of in vivo biological images by use of optical coherence tomography

G. J. Tearney, B. E. Bouma, S. A. Boppart, B. Golubovic, E. A. Swanson, J. G. Fujimoto

Research output: Contribution to journal › Article › peer-review

Abstract

The development of techniques for high-speed image acquisition in optical coherence tomography (OCT) systems is essential for suppressing motion artifacts when one is imaging living systems. We describe a new OCT system for performing micrometer-scale, cross-sectional optical imaging at four images/s. To achieve OCT image-acquisition times of less than 1 s, we use a piezoelectric fiber stretcher to vary the reference arm delay. A Kerr-lens mode-locked chromium-doped forsterite laser is employed as the low-coherence source for the high-speed OCT system. Dynamic, motion-artifact-free in vivo imaging of a beating Xenopus laevis (African frog) heart is demonstrated.

Original language	English (US)
Pages (from-to)	1408-1410
Number of pages	3
Journal	Optics Letters
Volume	21
Issue number	17
DOIs	https://doi.org/10.1364/OL.21.001408
State	Published - Oct 1 1996
Externally published	Yes

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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10.1364/OL.21.001408

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title = "Rapid acquisition of in vivo biological images by use of optical coherence tomography",

abstract = "The development of techniques for high-speed image acquisition in optical coherence tomography (OCT) systems is essential for suppressing motion artifacts when one is imaging living systems. We describe a new OCT system for performing micrometer-scale, cross-sectional optical imaging at four images/s. To achieve OCT image-acquisition times of less than 1 s, we use a piezoelectric fiber stretcher to vary the reference arm delay. A Kerr-lens mode-locked chromium-doped forsterite laser is employed as the low-coherence source for the high-speed OCT system. Dynamic, motion-artifact-free in vivo imaging of a beating Xenopus laevis (African frog) heart is demonstrated.",

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AU - Bouma, B. E.

AU - Boppart, S. A.

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AU - Swanson, E. A.

AU - Fujimoto, J. G.

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AB - The development of techniques for high-speed image acquisition in optical coherence tomography (OCT) systems is essential for suppressing motion artifacts when one is imaging living systems. We describe a new OCT system for performing micrometer-scale, cross-sectional optical imaging at four images/s. To achieve OCT image-acquisition times of less than 1 s, we use a piezoelectric fiber stretcher to vary the reference arm delay. A Kerr-lens mode-locked chromium-doped forsterite laser is employed as the low-coherence source for the high-speed OCT system. Dynamic, motion-artifact-free in vivo imaging of a beating Xenopus laevis (African frog) heart is demonstrated.

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Rapid acquisition of in vivo biological images by use of optical coherence tomography

Abstract

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