Rapid 3D Extrusion of Synthetic Tumor Microenvironments

Joshua M. Grolman; Douglas Zhang; Andrew M. Smith; Jeffrey S. Moore; Kristopher A. Kilian

doi:10.1002/adma.201501729

Rapid 3D Extrusion of Synthetic Tumor Microenvironments

Joshua M. Grolman
, Douglas Zhang
, Andrew M. Smith
, Jeffrey S. Moore
, Kristopher A. Kilian

Research output: Contribution to journal › Article › peer-review

Abstract

The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.

Original language	English (US)
Pages (from-to)	5512-5517
Number of pages	6
Journal	Advanced Materials
Volume	27
Issue number	37
DOIs	https://doi.org/10.1002/adma.201501729
State	Published - Oct 1 2015

Keywords

microfluidics
patterned hydrogels
tissue engineering
tumor microenvironments

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

Online availability

10.1002/adma.201501729

Library availability

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title = "Rapid 3D Extrusion of Synthetic Tumor Microenvironments",

abstract = "The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.",

keywords = "microfluidics, patterned hydrogels, tissue engineering, tumor microenvironments",

author = "Grolman, \{Joshua M.\} and Douglas Zhang and Smith, \{Andrew M.\} and Moore, \{Jeffrey S.\} and Kilian, \{Kristopher A.\}",

note = "Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2015",

month = oct,

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doi = "10.1002/adma.201501729",

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volume = "27",

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journal = "Advanced Materials",

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AU - Grolman, Joshua M.

AU - Zhang, Douglas

AU - Smith, Andrew M.

AU - Moore, Jeffrey S.

AU - Kilian, Kristopher A.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.

AB - The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.

KW - microfluidics

KW - patterned hydrogels

KW - tissue engineering

KW - tumor microenvironments

UR - https://www.scopus.com/pages/publications/84942819697

UR - https://www.scopus.com/pages/publications/84942819697#tab=citedBy

U2 - 10.1002/adma.201501729

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AN - SCOPUS:84942819697

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JO - Advanced Materials

JF - Advanced Materials

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ER -

Rapid 3D Extrusion of Synthetic Tumor Microenvironments

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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