Rapid 3D Extrusion of Synthetic Tumor Microenvironments

Joshua M. Grolman; Douglas Zhang; Andrew M. Smith; Jeffrey S. Moore; Kristopher A. Kilian

doi:10.1002/adma.201501729

Rapid 3D Extrusion of Synthetic Tumor Microenvironments

Joshua M. Grolman, Douglas Zhang, Andrew M. Smith, Jeffrey S. Moore, Kristopher A. Kilian

Research output: Contribution to journal › Article › peer-review

Abstract

The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.

Original language	English (US)
Pages (from-to)	5512-5517
Number of pages	6
Journal	Advanced Materials
Volume	27
Issue number	37
DOIs	https://doi.org/10.1002/adma.201501729
State	Published - Oct 1 2015

Keywords

microfluidics
patterned hydrogels
tissue engineering
tumor microenvironments

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

Online availability

10.1002/adma.201501729

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title = "Rapid 3D Extrusion of Synthetic Tumor Microenvironments",

abstract = "The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.",

keywords = "microfluidics, patterned hydrogels, tissue engineering, tumor microenvironments",

author = "Grolman, {Joshua M.} and Douglas Zhang and Smith, {Andrew M.} and Moore, {Jeffrey S.} and Kilian, {Kristopher A.}",

note = "Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

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AU - Grolman, Joshua M.

AU - Zhang, Douglas

AU - Smith, Andrew M.

AU - Moore, Jeffrey S.

AU - Kilian, Kristopher A.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.

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KW - patterned hydrogels

KW - tissue engineering

KW - tumor microenvironments

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Rapid 3D Extrusion of Synthetic Tumor Microenvironments

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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