Abstract

The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.

Original languageEnglish (US)
Pages (from-to)5512-5517
Number of pages6
JournalAdvanced Materials
Volume27
Issue number37
DOIs
StatePublished - Oct 1 2015

Keywords

  • microfluidics
  • patterned hydrogels
  • tissue engineering
  • tumor microenvironments

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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