Radiosynthesis of [ 18F]fluoromethyldeoxyspergualin for molecular imaging of heat shock proteins

Pradip Ghosh, King C. Li, Daniel Y. Lee

Research output: Contribution to journalArticle

Abstract

To probe the in vivo role of stress response factors in normal physiology and in solid tumors we have designed a stable 18F-labeled molecular imaging agent based on a ligand for heat shock protein 70 (HSP70). We describe the synthesis of [ 18F] fluorodeoxymethylspergualin ([ 18F]MeDSG) as a new radiopharmaceutical probe using a prosthetic group, [ 18F]SFB, for efficient and rapid radiolabeling. Ongoing molecular imaging studies are under way to detect HSP70 expression in tumors by positron emission tomography.

Original languageEnglish (US)
Pages (from-to)609-613
Number of pages5
JournalApplied Radiation and Isotopes
Volume69
Issue number3
DOIs
StatePublished - Mar 1 2011
Externally publishedYes

Keywords

  • HSP70
  • Heat shock proteins
  • Methyldeoxyspergualin
  • Molecular imaging
  • Nuclear medicine
  • PET

ASJC Scopus subject areas

  • Radiation

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