TY - JOUR
T1 - Radical S-adenosylmethionine (SAM) enzymes in cofactor biosynthesis
T2 - A treasure trove of complex organic radical rearrangement reactions
AU - Mehta, Angad P.
AU - Abdelwahed, Sameh H.
AU - Mahanta, Nilkamal
AU - Fedoseyenko, Dmytro
AU - Philmus, Benjamin
AU - Cooper, Lisa E.
AU - Liu, Yiquan
AU - Jhulki, Isita
AU - Ealick, Steven E.
AU - Begley, Tadhg P.
N1 - Publisher Copyright:
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.
PY - 2015/2/13
Y1 - 2015/2/13
N2 - In this minireview, we describe the radical S-adenosylmethionine enzymes involved in the biosynthesis of thiamin, menaquinone, molybdopterin, coenzyme F420, and heme. Our focus is on the remarkably complex organic rearrangements involved, many of which have no precedent in organic or biological chemistry.
AB - In this minireview, we describe the radical S-adenosylmethionine enzymes involved in the biosynthesis of thiamin, menaquinone, molybdopterin, coenzyme F420, and heme. Our focus is on the remarkably complex organic rearrangements involved, many of which have no precedent in organic or biological chemistry.
UR - http://www.scopus.com/inward/record.url?scp=84922896576&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922896576&partnerID=8YFLogxK
U2 - 10.1074/jbc.R114.623793
DO - 10.1074/jbc.R114.623793
M3 - Article
C2 - 25477515
AN - SCOPUS:84922896576
SN - 0021-9258
VL - 290
SP - 3980
EP - 3986
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 7
ER -