Radical S-adenosylmethionine (SAM) enzymes in cofactor biosynthesis: A treasure trove of complex organic radical rearrangement reactions

Angad P. Mehta, Sameh H. Abdelwahed, Nilkamal Mahanta, Dmytro Fedoseyenko, Benjamin Philmus, Lisa E. Cooper, Yiquan Liu, Isita Jhulki, Steven E. Ealick, Tadhg P. Begley

Research output: Contribution to journalArticlepeer-review

Abstract

In this minireview, we describe the radical S-adenosylmethionine enzymes involved in the biosynthesis of thiamin, menaquinone, molybdopterin, coenzyme F420, and heme. Our focus is on the remarkably complex organic rearrangements involved, many of which have no precedent in organic or biological chemistry.

Original languageEnglish (US)
Pages (from-to)3980-3986
Number of pages7
JournalJournal of Biological Chemistry
Volume290
Issue number7
DOIs
StatePublished - Feb 13 2015
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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