Radical control for enantioselective Csp3–Csp3 cross-coupling

Ju Byeong Chae; Annika R. Holm; Liviu M. Mirica

doi:10.1038/s41929-024-01208-2

Radical control for enantioselective Csp³–Csp³ cross-coupling

Ju Byeong Chae, Annika R. Holm, Liviu M. Mirica

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

The enantioselective formation of Csp³–Csp³ bonds is still a substantial challenge in the synthesis of complex molecules. Now, a photocatalytic system has been developed for the enantioselective alkylation of α-amino Csp³−H bonds that promotes the generation of two different alkyl radicals, followed by their cross-coupling at a chiral nickel centre.

Original language	English (US)
Pages (from-to)	857-859
Number of pages	3
Journal	Nature Catalysis
Volume	7
Issue number	8
DOIs	https://doi.org/10.1038/s41929-024-01208-2
State	Published - Aug 2024

ASJC Scopus subject areas

Catalysis
Bioengineering
Biochemistry
Process Chemistry and Technology

Online availability

10.1038/s41929-024-01208-2

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Cite this

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