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Quantum and quantum-inspired optical and magnetic microscopy of molecules

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this talk I will present our work on two projects relevant to quantum sensing and imaging in the context of chemistry and biology. First, I will discuss an experimental demonstration of a new kind of super-resolution microscopy modality that in principle saturates the quantum Fisher information associated with resolving mutually incoherent point sources. The method could find utility in cases where simultaneously emitting point sources are to be continuously tracked, or when the size and/or aspect ratio of a subdiffraction object is to be accurately and efficiently assessed. Second, I will share how our group has repurposed commonly-used Alexa dyes as photoswitchable spin beacons that can be interfaced with single nitrogen-vacancy (NV) centers in diamond for correlative optical-magnetic resonance microscopy. This offers a possible way forward in the development of a general method for single-molecule nuclear magnetic resonance (NMR) spectroscopy. In this paper I will briefly summarize our findings on both topics, then expound upon some of the theory and simulation used to model the latter.

Original languageEnglish (US)
Title of host publicationQuantum Effects and Measurement Techniques in Biology and Biophotonics III
EditorsSergey V. Polyakov, Paige Derr, Youngchan Kim
PublisherSPIE
ISBN (Electronic)9781510696570
DOIs
StatePublished - Mar 5 2026
Event2026 3rd Quantum Effects and Measurement Techniques in Biology and Biophotonics - San Francisco, United States
Duration: Jan 18 2026Jan 20 2026

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume13872
ISSN (Print)1605-7422
ISSN (Electronic)2410-9045

Conference

Conference2026 3rd Quantum Effects and Measurement Techniques in Biology and Biophotonics
Country/TerritoryUnited States
CitySan Francisco
Period1/18/261/20/26

Keywords

  • fluorescence microscopy
  • nitrogen-vacancy centers
  • quantum metrology
  • quantum sensing
  • super-resolution

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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