Quantitative ultrasound history and successes

Ultrasound has been used for imaging and diagnostics for more than 50 years. During that time, the number of medical applications for ultrasonic imaging has increased dramatically. These increases in applicability have come with improved device technology, improved understanding of ultrasound interaction with tissues, and improved processing techniques. Over the past three decades, quantitative ultrasound (QUS) techniques have been explored to further improve medical diagnostics and monitor/assess therapeutic responses. The acceptance of QUS techniques has been slower in common medical practice than conventional ultrasonic imaging techniques like B-mode or Doppler. This is due mainly to a lack of technological capabilities to make use of these unique and beneficial imaging modes. However, with modern ultrasonic imaging devices, QUS techniques have found a new acceptance and are poised to make significant contributions to diagnostic medicine. In this chapter, we will examine the history of QUS techniques and their evolution over time along with significant contributions and successes that have been demonstrated over the years.