Quantitative Ultrasound: Experimental Implementation

The backscatter coefficient is a fundamental property of tissues, much like the attenuation and sound speed. From the backscatter coefficient, different scatterer properties describing the underlying tissue can be used to characterize tissue state. Furthermore, because the backscatter coefficient is a fundamental property of a tissue, estimation of the backscatter coefficient should be able to be computed with system and operator independence. To accomplish system- and operator-independent estimates of the backscatter coefficient, a calibration spectrum must be obtained at the same system settings as the settings used to scan a tissue. In this chapter, we discuss three approaches to obtaining a calibration spectrum and compare the engineering tradeoffs associated with each approach. In addition, methods for reducing deterministic noise in the backscatter coefficient spectrum are considered and implementation of these techniques is discussed.