Quantitative ultrasound assessment of ultrasound therapy in rodent mammary tumors: In vivo and ex vivo results

Jeremy Kemmerer, Goutam Ghoshal, Michael Oelze

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

High-intensity focused ultrasound (HIFU) is a promising means of non-invasive therapy for the treatment of tumors. Monitoring and assessment challenges for HIFU therapy remain, however, and ultrasound is under investigation to accomplish non-invasive treatment feedback. Quantitative ultrasound (QUS) was investigated for acute HIFU therapy assessment as well as temperature monitoring in a rat model mammary tumor both in vivo and ex vivo. In the in vivo study, 40 rodent mammary tumors were exposed to focused ultrasound produced by a 1-MHz single-element transducer (f/1.1) at three spatial-peak temporal-average intensity levels (335, 360, and 502 W/cm2). Ultrasound assessment scans were performed on each tumor before and again immediately after HIFU exposure using clinical (Ultrasonix L14/5, 3-8 MHz) and small-animal high-frequency (VisualSonics MS-200, 6-14 MHz) ultrasound systems.

Original languageEnglish (US)
Title of host publication2013 IEEE International Ultrasonics Symposium, IUS 2013
Pages1793-1796
Number of pages4
DOIs
StatePublished - Dec 1 2013
Event2013 IEEE International Ultrasonics Symposium, IUS 2013 - Prague, Czech Republic
Duration: Jul 21 2013Jul 25 2013

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2013 IEEE International Ultrasonics Symposium, IUS 2013
CountryCzech Republic
CityPrague
Period7/21/137/25/13

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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    Kemmerer, J., Ghoshal, G., & Oelze, M. (2013). Quantitative ultrasound assessment of ultrasound therapy in rodent mammary tumors: In vivo and ex vivo results. In 2013 IEEE International Ultrasonics Symposium, IUS 2013 (pp. 1793-1796). [6725111] (IEEE International Ultrasonics Symposium, IUS). https://doi.org/10.1109/ULTSYM.2013.0457