TY - GEN
T1 - Quantitative ultrasound assessment of ultrasound therapy in rodent mammary tumors
T2 - 2013 IEEE International Ultrasonics Symposium, IUS 2013
AU - Kemmerer, Jeremy
AU - Ghoshal, Goutam
AU - Oelze, Michael
PY - 2013
Y1 - 2013
N2 - High-intensity focused ultrasound (HIFU) is a promising means of non-invasive therapy for the treatment of tumors. Monitoring and assessment challenges for HIFU therapy remain, however, and ultrasound is under investigation to accomplish non-invasive treatment feedback. Quantitative ultrasound (QUS) was investigated for acute HIFU therapy assessment as well as temperature monitoring in a rat model mammary tumor both in vivo and ex vivo. In the in vivo study, 40 rodent mammary tumors were exposed to focused ultrasound produced by a 1-MHz single-element transducer (f/1.1) at three spatial-peak temporal-average intensity levels (335, 360, and 502 W/cm2). Ultrasound assessment scans were performed on each tumor before and again immediately after HIFU exposure using clinical (Ultrasonix L14/5, 3-8 MHz) and small-animal high-frequency (VisualSonics MS-200, 6-14 MHz) ultrasound systems.
AB - High-intensity focused ultrasound (HIFU) is a promising means of non-invasive therapy for the treatment of tumors. Monitoring and assessment challenges for HIFU therapy remain, however, and ultrasound is under investigation to accomplish non-invasive treatment feedback. Quantitative ultrasound (QUS) was investigated for acute HIFU therapy assessment as well as temperature monitoring in a rat model mammary tumor both in vivo and ex vivo. In the in vivo study, 40 rodent mammary tumors were exposed to focused ultrasound produced by a 1-MHz single-element transducer (f/1.1) at three spatial-peak temporal-average intensity levels (335, 360, and 502 W/cm2). Ultrasound assessment scans were performed on each tumor before and again immediately after HIFU exposure using clinical (Ultrasonix L14/5, 3-8 MHz) and small-animal high-frequency (VisualSonics MS-200, 6-14 MHz) ultrasound systems.
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U2 - 10.1109/ULTSYM.2013.0457
DO - 10.1109/ULTSYM.2013.0457
M3 - Conference contribution
AN - SCOPUS:84894312773
SN - 9781467356862
T3 - IEEE International Ultrasonics Symposium, IUS
SP - 1793
EP - 1796
BT - 2013 IEEE International Ultrasonics Symposium, IUS 2013
Y2 - 21 July 2013 through 25 July 2013
ER -