Quantitative ultrasound assessment of thermal damage in excised liver

Jeremy P. Kemmerer, Goutam Ghoshal, Michael L. Oelze

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Quantitative ultrasound (QUS) is a novel approach for characterizing tissue microstructure and changes in tissue microstructure due to therapy. In this report, we discuss changes in QUS parameters in liver tissues after being exposed to thermal insult. Effective scatterer diameter (ESD) and effective acoustic concentration (EAC) from the normalized backscattered power spectrum were examined in rat liver specimens heated in a degassed saline bath. Individual liver samples were bisected, with half of each sample heated to a therapeutic temperature of 60°C for 10 minutes and the other half held at 37°C. The ultrasonic backscatter and attenuation coefficient were then estimated at 37°C from both halves. ESD was observed to decrease by an average of 34% in exposed compared to unexposed sample sections, EAC increased by 18 dB, and the attenuation coefficient increased by 70%. Histological slides from these samples indicate cell size and/or concentration may be affected by heating. This work was supported by NIH R01-EB008992.

Original languageEnglish (US)
Title of host publication11th International Symposium on Therapeutic Ultrasound
Number of pages6
StatePublished - 2012
Event11th International Symposium on Therapeutic Ultrasound, ISTU 2011 - New York, NY, United States
Duration: Apr 11 2011Apr 13 2011

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


Other11th International Symposium on Therapeutic Ultrasound, ISTU 2011
Country/TerritoryUnited States
CityNew York, NY


  • backscatter coefficient
  • HIFU
  • quantitative ultrasound

ASJC Scopus subject areas

  • General Physics and Astronomy


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