TY - GEN
T1 - Quantitative ultrasound assessment of HIFU induced lesions in rodent liver
AU - Kemmerer, Jeremy
AU - Ghoshal, Goutam
AU - Oelze, Michael
PY - 2010
Y1 - 2010
N2 - Quantitative ultrasound (QUS) techniques have been used for tissue characterization by discriminating between tissues of differing microstructure. High Intensity Focused Ultrasound (HIFU) is a means for minimal or non-invasive therapy, which results in changes in tissue microstructure. However, significant challenges remain for the monitoring and assessment of HIFU therapy. Conventional B-mode imaging is not reliable for detection and assessment of thermal lesions produced by HIFU. Because of QUS sensitivity to microstructure changes, it was hypothesized that QUS could assess thermal lesions. A 1-MHz single-element focused transducer (f/1.1) was used to produce thermal lesions in ex-vivo rat liver. The focal intensities used to generate lesions were measured to be between 1500 and 2500 W/cm2 in degassed water using a calibrated needle hydrophone. These exposures were monitored using a clinical ultrasound array (L14-5, Ultrasonix). Treated and untreated regions as determined by histology and visual inspection were compared to parametric images of QUS parameters (Effective Scatterer Diameter (ESD), and Effective Acoustic Concentration (EAC)). An average increase in ESD of 15% was observed in three samples, while EAC estimates decreased by 4.3 dB. These findings suggest that QUS can be used for non-invasive assessment of thermal lesions.
AB - Quantitative ultrasound (QUS) techniques have been used for tissue characterization by discriminating between tissues of differing microstructure. High Intensity Focused Ultrasound (HIFU) is a means for minimal or non-invasive therapy, which results in changes in tissue microstructure. However, significant challenges remain for the monitoring and assessment of HIFU therapy. Conventional B-mode imaging is not reliable for detection and assessment of thermal lesions produced by HIFU. Because of QUS sensitivity to microstructure changes, it was hypothesized that QUS could assess thermal lesions. A 1-MHz single-element focused transducer (f/1.1) was used to produce thermal lesions in ex-vivo rat liver. The focal intensities used to generate lesions were measured to be between 1500 and 2500 W/cm2 in degassed water using a calibrated needle hydrophone. These exposures were monitored using a clinical ultrasound array (L14-5, Ultrasonix). Treated and untreated regions as determined by histology and visual inspection were compared to parametric images of QUS parameters (Effective Scatterer Diameter (ESD), and Effective Acoustic Concentration (EAC)). An average increase in ESD of 15% was observed in three samples, while EAC estimates decreased by 4.3 dB. These findings suggest that QUS can be used for non-invasive assessment of thermal lesions.
KW - HIFU
KW - Quantiative ultrasound
KW - Tissue characterization
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U2 - 10.1109/ULTSYM.2010.5935845
DO - 10.1109/ULTSYM.2010.5935845
M3 - Conference contribution
AN - SCOPUS:80054771142
SN - 9781457703829
T3 - Proceedings - IEEE Ultrasonics Symposium
SP - 1396
EP - 1399
BT - 2010 IEEE International Ultrasonics Symposium, IUS 2010
T2 - 2010 IEEE International Ultrasonics Symposium, IUS 2010
Y2 - 11 October 2010 through 14 October 2010
ER -