Quantitative structure-activity relations for γδ T cell activation by phosphoantigens

William Gossman, Eric Oldfield

Research output: Contribution to journalArticle

Abstract

γδ T cells help contribute to innate immunity and are activated by the natural phosphoantigens produced by the organisms responsible for causing, for example, tuberculosis, malaria, tularemia, and plague. They are also activated by synthetic phosphoantigens and are cytotoxic to tumor cells. Here, we show that it is now possible to accurately predict γδ T cell activation by both natural and synthetic phosphoantigens by using the quantitative structure-activity relationship (QSAR) techniques commonly used in drug design. This approach should be of use in developing novel immunotherapeutic agents as well as contributing to a better understanding of the immune system's response to infectious agents.

Original languageEnglish (US)
Pages (from-to)4868-4874
Number of pages7
JournalJournal of Medicinal Chemistry
Volume45
Issue number22
DOIs
StatePublished - Oct 24 2002

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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