Quantitative multispectral biosensing and 1D imaging using quasi-3D plasmonic crystals

Matthew E. Stewart, Nathan H. Mack, Viktor Malyarchuk, Julio A.N.T. Soares, Tae Woo Lee, Stephen K. Gray, Ralph G. Nuzzo, John A. Rogers

Research output: Contribution to journalArticlepeer-review


We developed a class of quasi-3D plasmonic crystal that consists of multilayered, regular arrays of subwavelength metal nanostructures. The complex, highly sensitive structure of the optical transmission spectra of these crystals makes them especially well suited for sensing applications. Coupled with quantitative electrodynamics modeling of their optical response, they enable full multiwave-length spectroscopic detection of molecular binding events with sensitivities that correspond to small fractions of a monolayer. The high degree of spatial uniformity of the crystals, formed by a soft nanoimprint technique, provides the ability to image binding events over large areas with micrometer spatial resolution. These features, together with compact form factors, low-cost fabrication procedures, simple readout apparatus, and ability for direct integration into microfluidic networks and arrays, suggest promise for these devices in label-free bioanalytical detection systems.

Original languageEnglish (US)
Pages (from-to)17143-17148
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number46
StatePublished - Nov 14 2006


  • Chemical sensing
  • Nanoimprint lithography
  • Optical transmission spectra
  • Surface plasmons

ASJC Scopus subject areas

  • Genetics
  • General


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