Quantitative high-throughput population dynamics in continuous-culture by automated microscopy

Jason Merritt, Seppe Kuehn

Research output: Contribution to journalArticle

Abstract

We present a high-throughput method to measure abundance dynamics in microbial communities sustained in continuous-culture. Our method uses custom epi-fluorescence microscopes to automatically image single cells drawn from a continuously-cultured population while precisely controlling culture conditions. For clonal populations of Escherichia coli our instrument reveals history-dependent resilience and growth rate dependent aggregation.

Original languageEnglish (US)
Article number33173
JournalScientific reports
Volume6
DOIs
StatePublished - Sep 12 2016

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