Quantitative acoustical assessment of wound maturation with acoustic microscopy

Preliminary results of the ultrasonic characterization of cutaneous wound tissue and surrounding margin, obtained with the scanning laser acoustic microscope, show an increase in the speed of sound and in the acoustic heterogeneity as a function of wound age. As the wound age increased, the following results were noted: (1) The wound area, initially quite homogeneous in acoustic appearance, became more heterogeneous; (2) the acoustic appearance of the wound tended to become similar to that of the adjacent tissue; and (3) the ultrasonic velocity of the wound area increased from a range of 1540–1575 m/s at 7 days to a range of 1700–2000 m/s at 35 days.