Quantification of signal detection performance degradation induced by phase-retrieval in propagation-based x-ray phase-contrast imaging

Cheng Ying Chou, Mark A. Anastasio

Research output: Chapter in Book/Report/Conference proceedingConference contribution


In propagation-based X-ray phase-contrast (PB XPC) imaging, the measured image contains a mixture of absorption- and phase-contrast. To obtain separate images of the projected absorption and phase (i.e., refractive) properties of a sample, phase retrieval methods can be employed. It has been suggested that phase-retrieval can always improve image quality in PB XPC imaging. However, when objective (task-based) measures of image quality are employed, this is not necessarily true and phase retrieval can be detrimental. In this work, signal detection theory is utilized to quantify the performance of a Hotelling observer (HO) for detecting a known signal in a known background. Two cases are considered. In the first case, the HO acts directly on the measured intensity data. In the second case, the HO acts on either the retrieved phase or absorption image. We demonstrate that the performance of the HO is superior when acting on the measured intensity data. The loss of task-specific information induced by phase-retrieval is quantified by computing the efficiency of the HO as the ratio of the test statistic signal-to-noise ratio (SNR) for the two cases. The effect of the system geometry on this efficiency is systematically investigated. Our findings confirm that phase-retrieval can impair signal detection performance in XPC imaging.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2016
Subtitle of host publicationPhysics of Medical Imaging
EditorsDespina Kontos, Joseph Y. Lo, Thomas G. Flohr
ISBN (Electronic)9781510600188
StatePublished - 2016
Externally publishedYes
EventMedical Imaging 2016: Physics of Medical Imaging - San Diego, United States
Duration: Feb 28 2016Mar 2 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2016: Physics of Medical Imaging
Country/TerritoryUnited States
CitySan Diego


  • Hotelling observer
  • phase-contrast
  • signal-to-noise ratio
  • X-ray

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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