QPI for prostate cancer diagnosis: Quantitative separation of Gleason grades 3 and 4

Shamira Sridharan, Virgilia Macias, Krishnarao Tangella, Andre Kajdacsy-Balla, Gabriel Popescu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

1 in 7 men receive a diagnosis of prostate cancer in their lifetime. The aggressiveness of the treatment plan adopted by the patient is strongly influenced by Gleason grade. Gleason grade is determined by the pathologist based on the level of glandular formation and complexity seen in the patient's biopsy. However, studies have shown that the disagreement rate between pathologists on Gleason grades 3 and 4 is high and this affects treatment options. We used quantitative phase imaging to develop an objective method for Gleason grading. Using the glandular solidity, which is the ratio of the area of the gland to a convex hull fit around it, and anisotropy of light scattered from the stroma immediately adjoining the gland, we were able to quantitatively separate Gleason grades 3 and 4 with 81% accuracy in 43 cases marked as difficult by pathologists.

Original languageEnglish (US)
Title of host publicationQuantitative Phase Imaging
EditorsYongKeun Park, Gabriel Popescu
PublisherSPIE
ISBN (Electronic)9781628414264
DOIs
StatePublished - Jan 1 2015
Event1st Conference on Quantitative Phase Imaging, QPI 2015 - San Francisco, United States
Duration: Feb 7 2015Feb 10 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9336
ISSN (Print)1605-7422

Other

Other1st Conference on Quantitative Phase Imaging, QPI 2015
CountryUnited States
CitySan Francisco
Period2/7/152/10/15

Fingerprint

Biopsy
grade
Prostatic Neoplasms
Anisotropy
cancer
Imaging techniques
glands
Neoplasm Grading
Light
Therapeutics
life (durability)
anisotropy
Pathologists

Keywords

  • Gleason grading
  • cancer diagnosis
  • interferometry
  • label-free imaging
  • microscopy
  • prostate cancer
  • quantitative phase imaging
  • spatial light interference microscopy
  • tissue microarray

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Sridharan, S., Macias, V., Tangella, K., Kajdacsy-Balla, A., & Popescu, G. (2015). QPI for prostate cancer diagnosis: Quantitative separation of Gleason grades 3 and 4. In Y. Park, & G. Popescu (Eds.), Quantitative Phase Imaging [93361U] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9336). SPIE. https://doi.org/10.1117/12.2080067

QPI for prostate cancer diagnosis : Quantitative separation of Gleason grades 3 and 4. / Sridharan, Shamira; Macias, Virgilia; Tangella, Krishnarao; Kajdacsy-Balla, Andre; Popescu, Gabriel.

Quantitative Phase Imaging. ed. / YongKeun Park; Gabriel Popescu. SPIE, 2015. 93361U (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9336).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sridharan, S, Macias, V, Tangella, K, Kajdacsy-Balla, A & Popescu, G 2015, QPI for prostate cancer diagnosis: Quantitative separation of Gleason grades 3 and 4. in Y Park & G Popescu (eds), Quantitative Phase Imaging., 93361U, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9336, SPIE, 1st Conference on Quantitative Phase Imaging, QPI 2015, San Francisco, United States, 2/7/15. https://doi.org/10.1117/12.2080067
Sridharan S, Macias V, Tangella K, Kajdacsy-Balla A, Popescu G. QPI for prostate cancer diagnosis: Quantitative separation of Gleason grades 3 and 4. In Park Y, Popescu G, editors, Quantitative Phase Imaging. SPIE. 2015. 93361U. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2080067
Sridharan, Shamira ; Macias, Virgilia ; Tangella, Krishnarao ; Kajdacsy-Balla, Andre ; Popescu, Gabriel. / QPI for prostate cancer diagnosis : Quantitative separation of Gleason grades 3 and 4. Quantitative Phase Imaging. editor / YongKeun Park ; Gabriel Popescu. SPIE, 2015. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
@inproceedings{9bbab53b207e4f1abd1b2edacd6501b7,
title = "QPI for prostate cancer diagnosis: Quantitative separation of Gleason grades 3 and 4",
abstract = "1 in 7 men receive a diagnosis of prostate cancer in their lifetime. The aggressiveness of the treatment plan adopted by the patient is strongly influenced by Gleason grade. Gleason grade is determined by the pathologist based on the level of glandular formation and complexity seen in the patient's biopsy. However, studies have shown that the disagreement rate between pathologists on Gleason grades 3 and 4 is high and this affects treatment options. We used quantitative phase imaging to develop an objective method for Gleason grading. Using the glandular solidity, which is the ratio of the area of the gland to a convex hull fit around it, and anisotropy of light scattered from the stroma immediately adjoining the gland, we were able to quantitatively separate Gleason grades 3 and 4 with 81{\%} accuracy in 43 cases marked as difficult by pathologists.",
keywords = "Gleason grading, cancer diagnosis, interferometry, label-free imaging, microscopy, prostate cancer, quantitative phase imaging, spatial light interference microscopy, tissue microarray",
author = "Shamira Sridharan and Virgilia Macias and Krishnarao Tangella and Andre Kajdacsy-Balla and Gabriel Popescu",
year = "2015",
month = "1",
day = "1",
doi = "10.1117/12.2080067",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "YongKeun Park and Gabriel Popescu",
booktitle = "Quantitative Phase Imaging",

}

TY - GEN

T1 - QPI for prostate cancer diagnosis

T2 - Quantitative separation of Gleason grades 3 and 4

AU - Sridharan, Shamira

AU - Macias, Virgilia

AU - Tangella, Krishnarao

AU - Kajdacsy-Balla, Andre

AU - Popescu, Gabriel

PY - 2015/1/1

Y1 - 2015/1/1

N2 - 1 in 7 men receive a diagnosis of prostate cancer in their lifetime. The aggressiveness of the treatment plan adopted by the patient is strongly influenced by Gleason grade. Gleason grade is determined by the pathologist based on the level of glandular formation and complexity seen in the patient's biopsy. However, studies have shown that the disagreement rate between pathologists on Gleason grades 3 and 4 is high and this affects treatment options. We used quantitative phase imaging to develop an objective method for Gleason grading. Using the glandular solidity, which is the ratio of the area of the gland to a convex hull fit around it, and anisotropy of light scattered from the stroma immediately adjoining the gland, we were able to quantitatively separate Gleason grades 3 and 4 with 81% accuracy in 43 cases marked as difficult by pathologists.

AB - 1 in 7 men receive a diagnosis of prostate cancer in their lifetime. The aggressiveness of the treatment plan adopted by the patient is strongly influenced by Gleason grade. Gleason grade is determined by the pathologist based on the level of glandular formation and complexity seen in the patient's biopsy. However, studies have shown that the disagreement rate between pathologists on Gleason grades 3 and 4 is high and this affects treatment options. We used quantitative phase imaging to develop an objective method for Gleason grading. Using the glandular solidity, which is the ratio of the area of the gland to a convex hull fit around it, and anisotropy of light scattered from the stroma immediately adjoining the gland, we were able to quantitatively separate Gleason grades 3 and 4 with 81% accuracy in 43 cases marked as difficult by pathologists.

KW - Gleason grading

KW - cancer diagnosis

KW - interferometry

KW - label-free imaging

KW - microscopy

KW - prostate cancer

KW - quantitative phase imaging

KW - spatial light interference microscopy

KW - tissue microarray

UR - http://www.scopus.com/inward/record.url?scp=84931334993&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84931334993&partnerID=8YFLogxK

U2 - 10.1117/12.2080067

DO - 10.1117/12.2080067

M3 - Conference contribution

AN - SCOPUS:84931334993

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Quantitative Phase Imaging

A2 - Park, YongKeun

A2 - Popescu, Gabriel

PB - SPIE

ER -