Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption

John M. Sanders, Yongcheng Song, Julian M.W. Chan, Yonghui Zhang, Samuel Jennings, Thomas Kosztowski, Sarah Odeh, Ryan Flessner, Christine Schwerdtfeger, Evangelia Kotsikorou, Gary A. Meints, Aurora Ortiz Gómez, Dolores González-Pacanowska, Amy M. Raker, Hong Wang, Ermond R. Van Beek, Socrates E. Papapoulos, Craig T. Morita, Eric Oldfield

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Biochemistry, Genetics and Molecular Biology