Pyridine inhibitor binding to the 4Fe-4S protein A. aeolicus IspH (LytB): A HYSCORE investigation

Weixue Wang, Jikun Li, Ke Wang, Tatyana I. Smirnova, Eric Oldfield

Research output: Contribution to journalArticlepeer-review

Abstract

IspH is a 4Fe-4S protein that carries out an essential reduction step in isoprenoid biosynthesis. Using hyperfine sublevel correlation (HYSCORE) spectroscopy, we show that pyridine inhibitors of IspH directly bind to the unique fourth Fe in the 4Fe-4S cluster, opening up new routes to inhibitor design, of interest in the context of both anti-bacterial as well as anti-malarial drug discovery.

Original languageEnglish (US)
Pages (from-to)6525-6528
Number of pages4
JournalJournal of the American Chemical Society
Volume133
Issue number17
DOIs
StatePublished - May 4 2011

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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