Putting the "control" in metabolic control analysis

Christopher V. Rao, Herbert M. Sauro, Adam P. Arkin

Research output: Contribution to journalConference articlepeer-review


Metabolic control analysis is a framework for characterizing the parametric sensitivity of metabolic pathways and genetic networks. We establish a connection between metabolic control analysis and control theory. The main result is that we can use classical control theory and the associated signal-flow (block) diagrams to analyze biochemical reaction networks and that many results in metabolic control analysis have direct counterparts in control. In the process, we illustrate how some problems in biochemical network analysis can be reformulated in a control-theoretic framework.

Original languageEnglish (US)
Pages (from-to)1001-1006
Number of pages6
JournalIFAC Proceedings Volumes (IFAC-PapersOnline)
Issue number9
StatePublished - 2004
Externally publishedYes
Event7th IFAC Symposium on Dynamics and Control of Process Systems, DYCOPS 2004 - Cambridge, United States
Duration: Jul 5 2004Jul 7 2004


  • Biology
  • Metabolic control analysis (MCA)
  • Networks
  • Sensitivity

ASJC Scopus subject areas

  • Control and Systems Engineering


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