Abstract
Metabolic control analysis is a framework for characterizing the parametric sensitivity of metabolic pathways and genetic networks. We establish a connection between metabolic control analysis and control theory. The main result is that we can use classical control theory and the associated signal-flow (block) diagrams to analyze biochemical reaction networks and that many results in metabolic control analysis have direct counterparts in control. In the process, we illustrate how some problems in biochemical network analysis can be reformulated in a control-theoretic framework.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1001-1006 |
| Number of pages | 6 |
| Journal | IFAC Proceedings Volumes (IFAC-PapersOnline) |
| Volume | 37 |
| Issue number | 9 |
| State | Published - 2004 |
| Externally published | Yes |
| Event | 7th IFAC Symposium on Dynamics and Control of Process Systems, DYCOPS 2004 - Cambridge, United States Duration: Jul 5 2004 → Jul 7 2004 |
Keywords
- Biology
- Metabolic control analysis (MCA)
- Networks
- Sensitivity
ASJC Scopus subject areas
- Control and Systems Engineering