@article{b862205be98e410b8e172a6100dd40fc,
title = "Pulmonary toxicity of cyclophosphamide: A 1-year study",
abstract = "The development of cyclophosphamide-induced pulmonary lesions over a 1-year period was studied in mice. Male BALB/c mice received a single intraperitoneal injection of 100 mg/kg of cyclophosphamide. Within 3 weeks there were scattered foci of intraalveolar foamy macrophages. With time, these foci increased in size and, 1 year later, occupied large areas in all lung lobes. There was also diffuse interstitial fibrosis. Chemical determination done 3, 12, 24, and 52 weeks after cyclophosphamide showed that lungs of animals treated with cyclophosphamide had significantly more hydroxyproline per lung than controls. One year after cyclophosphamide pressure-volume curves measured in vivo were shifted down and to the right and total lung volumes were decreased. A single injection of cyclophosphamide produced an irreversible and progressive pulmonary lesion.",
author = "Morse, {C. C.} and C. Sigler and S. Lock and Hakkinen, {P. J.} and Haschek, {W. M.} and Witschi, {H. P.}",
note = "Funding Information: r The U.S. Government{\textquoteright}s right to retain a nonexclusive royalty-free license in and to the copyright covering this paper, for governmental purposes, is acknowledged. This research was sponsored by the Offrce of Health and Environmental Research, U.S. Department of Energy under Contract DE-AC05-840R21400 with the Martin Marietta Energy Systems, Inc., and Subcontract 3322 from the Biology Division to the University of Tennessee, Knoxville. {\textquoteright} Present address: Department of Pathobiology. University of Pennsylvania, School of Veterinary Medicine, Philadelphia, Pa. 19104. 3 Present address: PHS/FDA Bureau of Veterinary Medicine, Rockville. Md. 20857. 4 Present address: The Procter & Gamble Co., Cincinnati, Ohio 45202. 5 Present address: College of Veterinary Medicine, University of Illinois, Urbana, Ill. 61801. 6 To whom reprint requests should be addressed: Biology Division, Oak Ridge National Laboratory, P.O. Box Y, Oak Ridge, Tenn. 3783 I.",
year = "1985",
month = apr,
doi = "10.1016/0014-4800(85)90031-0",
language = "English (US)",
volume = "42",
pages = "251--260",
journal = "Experimental and Molecular Pathology",
issn = "0014-4800",
publisher = "Academic Press Inc.",
number = "2",
}