Pubertal ovarian hormone exposure reduces the number of myelinated axons in the splenium of the rat corpus callosum

M. A. Yates, J. M. Juraska

Research output: Contribution to journalArticlepeer-review

Abstract

The size of the female rat corpus callosum decreases in response to pubertal ovarian hormone exposure, but the underlying changes in axonal composition have not been examined. In the current study, animals underwent ovariectomy or sham surgery at day 20, and the number of myelinated and unmyelinated axons were examined in young adulthood (2 months) using electron microscopy. Ovariectomized animals had a greater number of myelinated axons compared to intact animals, while total axon number was not affected. Ovarian hormone exposure seems to limit the number of axons that become myelinated in the splenium, while not affecting the number of axons crossing through the region.

Original languageEnglish (US)
Pages (from-to)284-287
Number of pages4
JournalExperimental Neurology
Volume209
Issue number1
DOIs
StatePublished - Jan 2008

Keywords

  • Adolescence
  • Corticosteroids
  • Estrogen
  • Myelin
  • Oligdodendrocyte
  • Progesterone

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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