Abstract
Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.
Original language | English (US) |
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Pages (from-to) | 4275-4278 |
Number of pages | 4 |
Journal | Infection and immunity |
Volume | 72 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Immunology
- Infectious Diseases