Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.
|Original language||English (US)|
|Number of pages||4|
|Journal||Infection and immunity|
|State||Published - Jul 2004|
ASJC Scopus subject areas
- Infectious Diseases