Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice

Gee W. Lau, Huimin Ran, Fansheng Kong, Daniel J. Hassett, Dimitri Mavrodi

Research output: Contribution to journalArticle

Abstract

Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.

Original languageEnglish (US)
Pages (from-to)4275-4278
Number of pages4
JournalInfection and immunity
Volume72
Issue number7
DOIs
StatePublished - Jul 1 2004
Externally publishedYes

Fingerprint

Pyocyanine
Pseudomonas aeruginosa
Lung
Infection
Cystic Fibrosis
Respiratory Tract Infections
Oxidation-Reduction
Necrosis
Epithelial Cells

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice. / Lau, Gee W.; Ran, Huimin; Kong, Fansheng; Hassett, Daniel J.; Mavrodi, Dimitri.

In: Infection and immunity, Vol. 72, No. 7, 01.07.2004, p. 4275-4278.

Research output: Contribution to journalArticle

Lau, Gee W. ; Ran, Huimin ; Kong, Fansheng ; Hassett, Daniel J. ; Mavrodi, Dimitri. / Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice. In: Infection and immunity. 2004 ; Vol. 72, No. 7. pp. 4275-4278.
@article{021c68c8e24e452eb5d61792f81b8f5f,
title = "Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice",
abstract = "Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.",
author = "Lau, {Gee W.} and Huimin Ran and Fansheng Kong and Hassett, {Daniel J.} and Dimitri Mavrodi",
year = "2004",
month = "7",
day = "1",
doi = "10.1128/IAI.72.7.4275-4278.2004",
language = "English (US)",
volume = "72",
pages = "4275--4278",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "7",

}

TY - JOUR

T1 - Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice

AU - Lau, Gee W.

AU - Ran, Huimin

AU - Kong, Fansheng

AU - Hassett, Daniel J.

AU - Mavrodi, Dimitri

PY - 2004/7/1

Y1 - 2004/7/1

N2 - Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.

AB - Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.

UR - http://www.scopus.com/inward/record.url?scp=3042550379&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042550379&partnerID=8YFLogxK

U2 - 10.1128/IAI.72.7.4275-4278.2004

DO - 10.1128/IAI.72.7.4275-4278.2004

M3 - Article

C2 - 15213173

AN - SCOPUS:3042550379

VL - 72

SP - 4275

EP - 4278

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 7

ER -