Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice

Gee W. Lau; Huimin Ran; Fansheng Kong; Daniel J. Hassett; Dimitri Mavrodi

doi:10.1128/IAI.72.7.4275-4278.2004

Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice

Gee W. Lau, Huimin Ran, Fansheng Kong, Daniel J. Hassett, Dimitri Mavrodi

Research output: Contribution to journal › Article › peer-review

Abstract

Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.

Original language	English (US)
Pages (from-to)	4275-4278
Number of pages	4
Journal	Infection and immunity
Volume	72
Issue number	7
DOIs	https://doi.org/10.1128/IAI.72.7.4275-4278.2004
State	Published - Jul 2004
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.72.7.4275-4278.2004

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abstract = "Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.",

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AU - Kong, Fansheng

AU - Hassett, Daniel J.

AU - Mavrodi, Dimitri

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Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice

Abstract

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