Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice

Gee W. Lau, Huimin Ran, Fansheng Kong, Daniel J. Hassett, Dimitri Mavrodi

Research output: Contribution to journalArticle

Abstract

Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.

Original languageEnglish (US)
Pages (from-to)4275-4278
Number of pages4
JournalInfection and immunity
Volume72
Issue number7
DOIs
StatePublished - Jul 1 2004

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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