Pseudomonas aeruginosa biofilm infections in cystic fibrosis: Insights into pathogenic processes and treatment strategies

Daniel J. Hassett, Thomas R. Korfhagen, Randall T. Irvin, Michael J. Schurr, Karin Sauer, Gee Lau, Mark D. Sutton, Hongwei Yu, Niels Hoiby

Research output: Contribution to journalReview article

Abstract

Importance of the field: CF airway mucus can be infected by opportunistic microorganisms, notably Pseudomonas aeruginosa. Once organisms are established as biofilms, even the most potent antibiotics have little effect on their viability, especially during late-stage chronic infections. Better understanding of the mechanisms used by P. aeruginosa to circumvent host defenses and therapeutic intervention strategies is critical for advancing novel treatment strategies. Areas covered in this review: Inflammatory injury in CF lung, role of neutrophils in pathogenesis, P. aeruginosa biofilms, mucoidy and its relationship with poor airway oxygenation, mechanisms by which P. aeruginosa biofilms in the CF airway can be killed. What the reader will gain: An understanding of the processes that P. aeruginosa undergoes during CF airway disease and clues to better treat such infections in future. Take home message: The course of CF airway disease is a process involving host and microbial factors that often dictate frequency of pulmonary exacerbations, thus affecting the overall course. In the past decade significant discoveries have been made regarding the pathogenic processes used by P. aeruginosa to bypass the immune system. Many new and exciting features of P. aeruginosa now illuminate weaknesses in the organism that may render it susceptible to inexpensive compounds that force its own destruction.

Original languageEnglish (US)
Pages (from-to)117-130
Number of pages14
JournalExpert Opinion on Therapeutic Targets
Volume14
Issue number2
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

Fingerprint

Biofilms
Cystic Fibrosis
Pseudomonas aeruginosa
Infection
Oxygenation
Immune system
Microorganisms
Lung
Mucus
Anti-Bacterial Agents
Immune System
Neutrophils
Wounds and Injuries

Keywords

  • Alginate
  • Alternative treatment strategies
  • Biofilms
  • Cystic fibrosis
  • Dispersion
  • Pseudomonas aeruginosa

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Pseudomonas aeruginosa biofilm infections in cystic fibrosis : Insights into pathogenic processes and treatment strategies. / Hassett, Daniel J.; Korfhagen, Thomas R.; Irvin, Randall T.; Schurr, Michael J.; Sauer, Karin; Lau, Gee; Sutton, Mark D.; Yu, Hongwei; Hoiby, Niels.

In: Expert Opinion on Therapeutic Targets, Vol. 14, No. 2, 01.02.2010, p. 117-130.

Research output: Contribution to journalReview article

Hassett, Daniel J. ; Korfhagen, Thomas R. ; Irvin, Randall T. ; Schurr, Michael J. ; Sauer, Karin ; Lau, Gee ; Sutton, Mark D. ; Yu, Hongwei ; Hoiby, Niels. / Pseudomonas aeruginosa biofilm infections in cystic fibrosis : Insights into pathogenic processes and treatment strategies. In: Expert Opinion on Therapeutic Targets. 2010 ; Vol. 14, No. 2. pp. 117-130.
@article{751ebe81143c454bbf5c23263f6d05bb,
title = "Pseudomonas aeruginosa biofilm infections in cystic fibrosis: Insights into pathogenic processes and treatment strategies",
abstract = "Importance of the field: CF airway mucus can be infected by opportunistic microorganisms, notably Pseudomonas aeruginosa. Once organisms are established as biofilms, even the most potent antibiotics have little effect on their viability, especially during late-stage chronic infections. Better understanding of the mechanisms used by P. aeruginosa to circumvent host defenses and therapeutic intervention strategies is critical for advancing novel treatment strategies. Areas covered in this review: Inflammatory injury in CF lung, role of neutrophils in pathogenesis, P. aeruginosa biofilms, mucoidy and its relationship with poor airway oxygenation, mechanisms by which P. aeruginosa biofilms in the CF airway can be killed. What the reader will gain: An understanding of the processes that P. aeruginosa undergoes during CF airway disease and clues to better treat such infections in future. Take home message: The course of CF airway disease is a process involving host and microbial factors that often dictate frequency of pulmonary exacerbations, thus affecting the overall course. In the past decade significant discoveries have been made regarding the pathogenic processes used by P. aeruginosa to bypass the immune system. Many new and exciting features of P. aeruginosa now illuminate weaknesses in the organism that may render it susceptible to inexpensive compounds that force its own destruction.",
keywords = "Alginate, Alternative treatment strategies, Biofilms, Cystic fibrosis, Dispersion, Pseudomonas aeruginosa",
author = "Hassett, {Daniel J.} and Korfhagen, {Thomas R.} and Irvin, {Randall T.} and Schurr, {Michael J.} and Karin Sauer and Gee Lau and Sutton, {Mark D.} and Hongwei Yu and Niels Hoiby",
year = "2010",
month = "2",
day = "1",
doi = "10.1517/14728220903454988",
language = "English (US)",
volume = "14",
pages = "117--130",
journal = "Expert Opinion on Therapeutic Targets",
issn = "1472-8222",
publisher = "Informa Healthcare",
number = "2",

}

TY - JOUR

T1 - Pseudomonas aeruginosa biofilm infections in cystic fibrosis

T2 - Insights into pathogenic processes and treatment strategies

AU - Hassett, Daniel J.

AU - Korfhagen, Thomas R.

AU - Irvin, Randall T.

AU - Schurr, Michael J.

AU - Sauer, Karin

AU - Lau, Gee

AU - Sutton, Mark D.

AU - Yu, Hongwei

AU - Hoiby, Niels

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Importance of the field: CF airway mucus can be infected by opportunistic microorganisms, notably Pseudomonas aeruginosa. Once organisms are established as biofilms, even the most potent antibiotics have little effect on their viability, especially during late-stage chronic infections. Better understanding of the mechanisms used by P. aeruginosa to circumvent host defenses and therapeutic intervention strategies is critical for advancing novel treatment strategies. Areas covered in this review: Inflammatory injury in CF lung, role of neutrophils in pathogenesis, P. aeruginosa biofilms, mucoidy and its relationship with poor airway oxygenation, mechanisms by which P. aeruginosa biofilms in the CF airway can be killed. What the reader will gain: An understanding of the processes that P. aeruginosa undergoes during CF airway disease and clues to better treat such infections in future. Take home message: The course of CF airway disease is a process involving host and microbial factors that often dictate frequency of pulmonary exacerbations, thus affecting the overall course. In the past decade significant discoveries have been made regarding the pathogenic processes used by P. aeruginosa to bypass the immune system. Many new and exciting features of P. aeruginosa now illuminate weaknesses in the organism that may render it susceptible to inexpensive compounds that force its own destruction.

AB - Importance of the field: CF airway mucus can be infected by opportunistic microorganisms, notably Pseudomonas aeruginosa. Once organisms are established as biofilms, even the most potent antibiotics have little effect on their viability, especially during late-stage chronic infections. Better understanding of the mechanisms used by P. aeruginosa to circumvent host defenses and therapeutic intervention strategies is critical for advancing novel treatment strategies. Areas covered in this review: Inflammatory injury in CF lung, role of neutrophils in pathogenesis, P. aeruginosa biofilms, mucoidy and its relationship with poor airway oxygenation, mechanisms by which P. aeruginosa biofilms in the CF airway can be killed. What the reader will gain: An understanding of the processes that P. aeruginosa undergoes during CF airway disease and clues to better treat such infections in future. Take home message: The course of CF airway disease is a process involving host and microbial factors that often dictate frequency of pulmonary exacerbations, thus affecting the overall course. In the past decade significant discoveries have been made regarding the pathogenic processes used by P. aeruginosa to bypass the immune system. Many new and exciting features of P. aeruginosa now illuminate weaknesses in the organism that may render it susceptible to inexpensive compounds that force its own destruction.

KW - Alginate

KW - Alternative treatment strategies

KW - Biofilms

KW - Cystic fibrosis

KW - Dispersion

KW - Pseudomonas aeruginosa

UR - http://www.scopus.com/inward/record.url?scp=74949103972&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74949103972&partnerID=8YFLogxK

U2 - 10.1517/14728220903454988

DO - 10.1517/14728220903454988

M3 - Review article

C2 - 20055712

AN - SCOPUS:74949103972

VL - 14

SP - 117

EP - 130

JO - Expert Opinion on Therapeutic Targets

JF - Expert Opinion on Therapeutic Targets

SN - 1472-8222

IS - 2

ER -