Abstract
Pathophysiological alterations of liver sinusoidal endothelial cells (LSECs) impact liver and metabolism. LSEC fenestrations are pores facilitating lipoproteins and macromolecule transfer between blood and hepatocytes. The Gram negative bacterium Pseudomonas aeruginosa is one of the most common opportunistic nosocomial pathogens, especially in post-liver transplant recipients. Gram negative bacterial endotoxin (lipopolysaccharide, LPS) and the P. aeruginosa toxin, pyocyanin, have marked effects on LSECs, including loss of porosity (defenestration). Currently proposed mechanisms for sepsis-hyperlipidaemia, an important response to Gram negative bacterial sepsis, include tissue lipoprotein-lipase inhibition and increased hepatic triglyceride production. Owing to the well-substantiated role of LSECs in liver-allograft rejection and hyperlipidaemia, we propose defenestration of the LSEC is an additional cellular mechanism for sepsis-hyperlipidaemia, including pseudomonal sepsis post-liver transplantation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 615-621 |
| Number of pages | 7 |
| Journal | Pathology |
| Volume | 41 |
| Issue number | 7 |
| DOIs | |
| State | Published - Dec 2009 |
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Keywords
- Fenestration
- Hyperlipidaemia
- Liver sinusoidal endothelial cell
- Oxidative stress
- Pseudomonas aeruginosa
- Pyocyanin
- Sepsis
- Transplantation
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Pseudomonas aeruginosa and the hyperlipidaemia of sepsis. / Cheluvappa, Rajkumar; Denning, Gerene M.; Lau, Gee; Grimm, Michael C.; Hilmer, Sarah N.; Le Couteur, David G.
In: Pathology, Vol. 41, No. 7, 12.2009, p. 615-621.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pseudomonas aeruginosa and the hyperlipidaemia of sepsis
AU - Cheluvappa, Rajkumar
AU - Denning, Gerene M.
AU - Lau, Gee
AU - Grimm, Michael C.
AU - Hilmer, Sarah N.
AU - Le Couteur, David G.
PY - 2009/12
Y1 - 2009/12
N2 - Pathophysiological alterations of liver sinusoidal endothelial cells (LSECs) impact liver and metabolism. LSEC fenestrations are pores facilitating lipoproteins and macromolecule transfer between blood and hepatocytes. The Gram negative bacterium Pseudomonas aeruginosa is one of the most common opportunistic nosocomial pathogens, especially in post-liver transplant recipients. Gram negative bacterial endotoxin (lipopolysaccharide, LPS) and the P. aeruginosa toxin, pyocyanin, have marked effects on LSECs, including loss of porosity (defenestration). Currently proposed mechanisms for sepsis-hyperlipidaemia, an important response to Gram negative bacterial sepsis, include tissue lipoprotein-lipase inhibition and increased hepatic triglyceride production. Owing to the well-substantiated role of LSECs in liver-allograft rejection and hyperlipidaemia, we propose defenestration of the LSEC is an additional cellular mechanism for sepsis-hyperlipidaemia, including pseudomonal sepsis post-liver transplantation.
AB - Pathophysiological alterations of liver sinusoidal endothelial cells (LSECs) impact liver and metabolism. LSEC fenestrations are pores facilitating lipoproteins and macromolecule transfer between blood and hepatocytes. The Gram negative bacterium Pseudomonas aeruginosa is one of the most common opportunistic nosocomial pathogens, especially in post-liver transplant recipients. Gram negative bacterial endotoxin (lipopolysaccharide, LPS) and the P. aeruginosa toxin, pyocyanin, have marked effects on LSECs, including loss of porosity (defenestration). Currently proposed mechanisms for sepsis-hyperlipidaemia, an important response to Gram negative bacterial sepsis, include tissue lipoprotein-lipase inhibition and increased hepatic triglyceride production. Owing to the well-substantiated role of LSECs in liver-allograft rejection and hyperlipidaemia, we propose defenestration of the LSEC is an additional cellular mechanism for sepsis-hyperlipidaemia, including pseudomonal sepsis post-liver transplantation.
KW - Fenestration
KW - Hyperlipidaemia
KW - Liver sinusoidal endothelial cell
KW - Oxidative stress
KW - Pseudomonas aeruginosa
KW - Pyocyanin
KW - Sepsis
KW - Transplantation
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UR - http://www.scopus.com/inward/citedby.url?scp=72749112787&partnerID=8YFLogxK
U2 - 10.3109/00313020903257764
DO - 10.3109/00313020903257764
M3 - Article
C2 - 20001339
AN - SCOPUS:72749112787
VL - 41
SP - 615
EP - 621
JO - Pathology
JF - Pathology
SN - 0031-3025
IS - 7
ER -