Protein-Phospholipid interactions in blood clotting

James H Morrissey, Rebecca L. Davis-Harrison, Narjes Tavoosi, Ke Ke, Vincent Pureza, John M. Boettcher, Mary C. Clay, Chad Rienstra, Y. Zenmei Ohkubo, Taras V Pogorelov, Emad Tajkhorshid

Research output: Contribution to journalReview articlepeer-review

Abstract

Most steps of the blood clotting cascade require the assembly of a serine protease with its specific regulatory protein on a suitable phospholipid bilayer. Unfortunately, the molecular details of how blood clotting proteins bind to membrane surfaces remain poorly understood, owing to a dearth of techniques for studying protein-membrane interactions at high resolution. Our laboratories are tackling this question using a combination of approaches, including nanoscale membrane bilayers, solid-state NMR, and large-scale molecular dynamics simulations. These studies are now providing structural insights at atomic resolution into clotting protein-membrane interactions.

Original languageEnglish (US)
Pages (from-to)S23-S25
JournalThrombosis Research
Volume125
Issue numberSUPPL. 1
DOIs
StatePublished - Apr 2010

Keywords

  • Factor VIIa
  • Membranes
  • NMR
  • Phospholipids
  • Tissue Factor

ASJC Scopus subject areas

  • Hematology

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