Abstract

When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e.g. lipids). Here, we report that this protein coating, or corona, reduces the targeting capability of surface engineered NPs by screening the active sites of the targeting ligands.

Original languageEnglish (US)
Pages (from-to)2557-2559
Number of pages3
JournalChemical Communications
Volume49
Issue number25
DOIs
StatePublished - Feb 28 2013

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Protein corona significantly reduces active targeting yield'. Together they form a unique fingerprint.

Cite this