Protein corona significantly reduces active targeting yield

Vahid Mirshafiee; Morteza Mahmoudi; Kaiyan Lou; Jianjun Cheng; Mary L. Kraft

doi:10.1039/c3cc37307j

Protein corona significantly reduces active targeting yield

Vahid Mirshafiee, Morteza Mahmoudi, Kaiyan Lou, Jianjun Cheng, Mary L. Kraft

Research output: Contribution to journal › Article › peer-review

Abstract

When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e.g. lipids). Here, we report that this protein coating, or corona, reduces the targeting capability of surface engineered NPs by screening the active sites of the targeting ligands.

Original language	English (US)
Pages (from-to)	2557-2559
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	25
DOIs	https://doi.org/10.1039/c3cc37307j
State	Published - Feb 28 2013

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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10.1039/c3cc37307j

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title = "Protein corona significantly reduces active targeting yield",

abstract = "When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e.g. lipids). Here, we report that this protein coating, or corona, reduces the targeting capability of surface engineered NPs by screening the active sites of the targeting ligands.",

author = "Vahid Mirshafiee and Morteza Mahmoudi and Kaiyan Lou and Jianjun Cheng and Kraft, {Mary L.}",

year = "2013",

month = feb,

day = "28",

doi = "10.1039/c3cc37307j",

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publisher = "Royal Society of Chemistry",

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T1 - Protein corona significantly reduces active targeting yield

AU - Mirshafiee, Vahid

AU - Mahmoudi, Morteza

AU - Lou, Kaiyan

AU - Cheng, Jianjun

AU - Kraft, Mary L.

PY - 2013/2/28

Y1 - 2013/2/28

N2 - When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e.g. lipids). Here, we report that this protein coating, or corona, reduces the targeting capability of surface engineered NPs by screening the active sites of the targeting ligands.

AB - When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e.g. lipids). Here, we report that this protein coating, or corona, reduces the targeting capability of surface engineered NPs by screening the active sites of the targeting ligands.

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DO - 10.1039/c3cc37307j

M3 - Article

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JO - Chemical Communications

JF - Chemical Communications

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Protein corona significantly reduces active targeting yield

Abstract

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