Protein corona significantly reduces active targeting yield

Vahid Mirshafiee, Morteza Mahmoudi, Kaiyan Lou, Jianjun Cheng, Mary L. Kraft

Research output: Contribution to journalArticlepeer-review


When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e.g. lipids). Here, we report that this protein coating, or corona, reduces the targeting capability of surface engineered NPs by screening the active sites of the targeting ligands.

Original languageEnglish (US)
Pages (from-to)2557-2559
Number of pages3
JournalChemical Communications
Issue number25
StatePublished - Feb 28 2013

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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