Protein calorie malnutrition in young miniature swine: brain free amino acids

T. M. Badger, M. E. Tumbleson

Research output: Contribution to journalArticlepeer-review


The effects of protein calorie malnutrition (PCM) on cerebrum, cerebellum, and brainstem free amino acid levels were evaluated using 54 miniature swine. Eighteen piglets were weaned at each of the following ages: 5, 21, or 35 days. Within each age group, 6 piglets were assigned to one of three feeding regimes: 20% protein diet fed ad libitum, 5% protein diet fed ad libitum (malnourished), or 20% protein diet pair fed to malnourished piglets. At age 63 days, brain samples were collected and analyzed for free amino acid content. Patterns of free amino acids appeared to be related to age of PCM onset. Not only did the time of initiation determine which amino acid concentrations were altered, but also the manner of alteration and the area of the brain in which concentrations varied. Furthermore, different patterns of brain free amino acid concentrations were observed for protein deficient piglets than for pair fed piglets.

Original languageEnglish (US)
Pages (from-to)1329-1338
Number of pages10
JournalJournal of Nutrition
Issue number10
StatePublished - Oct 1974
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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