Prospects of molecular photoacoustic imaging at 1064 nm wavelength

Kimberly Homan, Seungsoo Kim, Yun Sheng Chen, Bo Wang, Srivalleesha Mallidi, Stanislav Emelianov

Research output: Contribution to journalArticlepeer-review


An analysis of the photoacoustic (PA) signal from murine tissue in vivo revealed several benefits of contrastenhanced PA imaging at a wavelength of 1064 nm. Of all the wavelengths tested in a range from 710 to 1064 nm, the background PA signal from tissue in vivo was lowest and more homogeneous at 1064 nm. For blood-laden tissue, the background PA signal was up to 70% less at 1064 nm. Furthermore, when plasmonic nanoparticles, such as silver nanoplates, were introduced in vivo as contrast agents, the contrast in PA images at 1064 nm increased 38% compared to 750 nm. Therefore, contrast-enhanced PA imaging at 1064 nm is advantageous because of the low and homogeneous signal from native tissue, enabling high contrast in PA imaging when exogenous, molecularly targeted agents are employed.

Original languageEnglish (US)
Pages (from-to)2663-2665
Number of pages3
JournalOptics Letters
Issue number15
StatePublished - Aug 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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