Proparathyroid hormone: Biosynthesis by human parathyroid adenomas

Joel F. Habener, Byron Kemper, John T. Potts, Alexander Rich

Research output: Contribution to journalArticle

Abstract

Biosynthesis of a precursor (proparathyroid hormone) to human parathyroid hormone was demonstrated during incubation of tissue from parathyroid adenomas. The proparathyroid hormone is labeled more rapidly than parathyroid hormone during incubation with amino acids labeled with carbon-14 and is progressively converted to the hormone. Apparent differences in the relative rate of conversion of precursor to hormone found in different tumors suggest that proparathyroid hormone may accumulate in some of the tumors and be secreted into the circulation.

Original languageEnglish (US)
Pages (from-to)630-633
Number of pages4
JournalScience
Volume178
Issue number4061
DOIs
StatePublished - Jan 1 1972
Externally publishedYes

ASJC Scopus subject areas

  • General

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