Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels

Keyphrases

• GIRK2 100%
• G Protein-coupled Inwardly Rectifying Potassium Channels 100%
• Caspase-dependent 100%
• Seizure Activity 100%
• Prolonged Seizures 100%
• GIRK1 62%
• Caspase-3 50%
• G Protein 25%
• Epileptic Seizure 25%
• GIRK Channel 25%
• Hippocampus 12%
• Cultured Hippocampal Neurons 12%
• Hippocampal Neurons 12%
• N-methyl-D-aspartate Receptor (NMDAR) 12%
• Binding Site 12%
• Cleavage Site 12%
• Channel Function 12%
• Seizure 12%
• Potassium 12%
• Neurotoxicity 12%
• Caspase-3 Activation 12%
• Presynaptic Inhibition 12%
• Neuronal Injury 12%
• Activation Receptor 12%
• Export Patterns 12%
• Kainate 12%
• Hippocampal Atrophy 12%
• Membrane Hyperpolarization 12%
• ER Export 12%
• Hippocampal Sclerosis 12%
• Role of Caspases 12%
• Channel Expression 12%
• Epileptiform Discharges 12%
• Direct Cleavage 12%
• Status Epilepticus 12%

Pharmacology, Toxicology and Pharmaceutical Science

• Caspase 3 100%
• Caspase 100%
• G Protein Coupled Inwardly Rectifying Potassium Channel 100%
• Guanine Nucleotide Binding Protein 40%
• Epileptic State 40%
• Injury 20%
• Binding Site 20%
• Isotopes of Potassium 20%
• Seizure 20%
• N Methyl Dextro Aspartic Acid Receptor 20%
• Excitotoxicity 20%
• Kainic Acid 20%
• Epileptic Discharge 20%
• Hippocampal Sclerosis 20%

Neuroscience

• G Protein-Coupled Inwardly-Rectifying Potassium Channel 100%
• Caspase 100%
• Caspase 3 100%
• G Protein 40%
• Status Epilepticus 40%
• Binding Site 20%
• Hippocampus 20%
• In Vivo 20%
• C-Terminus 20%
• NMDA Receptor 20%
• Synaptic Inhibition 20%
• Epileptic Seizure 20%
• Excitotoxicity 20%
• Hippocampal Sclerosis 20%