Progress in multiple-image radiography

Miles N. Wernick, Jovan G. Brankov, Dean Chapman, Yongyi Yang, Gocha Khelashvili, Mark A. Anastasio, Zhong Zhong, Christopher Parham, Jun Li, Carol Muehleman

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Conventional mammography is one of the most widely used diagnostic imaging techniques, but it has serious and well-known shortcomings, which are driving the development of innovative alternatives. Our group has been developing an x-ray imaging approach called multiple-image radiography (MIR), which shows promise as a potential alternative to conventional x-ray imaging (radiography). Like computed tomography (CT), MIR is a computed imaging technique, in which the images are not directly observed, but rather computed algorithmically. Whereas conventional radiography produces just one image depicting absorption effects, MIR simultaneously produces three images, showing separately the effects of absorption, refraction, and ultra-small-angle x-ray scattering. The latter two effects are caused by refractive-index variations in the object, which yield fine image details not seen in standard radiographs. MIR has the added benefits of dramatically lessening radiation dose, virtually eliminating scatter degradation, and lessening the importance of compressing the breast during imaging. In this paper we review progress to date on the MIR technique, focus on the basic physics and signal-processing issues involved in this new imaging method.

Original languageEnglish (US)
Title of host publicationComputational Imaging IV - Proceedings of SPIE-IS and T Electronic Imaging
StatePublished - Apr 17 2006
Externally publishedYes
EventComputational Imaging IV - San Jose, CA, United States
Duration: Jan 16 2006Jan 18 2006

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


ConferenceComputational Imaging IV
Country/TerritoryUnited States
CitySan Jose, CA


  • Diffraction enhanced imaging
  • Phase contrast imaging
  • Radiography
  • X-ray

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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