Progress in Cleveland Clinic-Nimbus total artificial heart development

H. Harasaki, K. Fukamachi, A. Massiello, J. F. Chen, S. C. Himley, F. Fukumura, K. Muramoto, S. Niu, K. Wika, C. R. Davies, P. M. McCarthy, R. J. Kiraly, D. C. Thomas, T. C. Rintoul, J. C. Carriker, T. R. Maher, K. C. Butler

Research output: Contribution to journalArticlepeer-review

Abstract

A totally implantable, Cleveland Clinic-Nimbus total artificial heart (TAH) uses electrohydraulic energy conversion and an automatic left master- alternate mode control scheme, with a filling sensitivity of 1.0 l/min/mmHg and a maximum output of 9.5 l/min. The TAHs were tested in 12 calves for 1- 120 days with normal major organ and blood cell function. Post-operative suppression of platelet aggregation recovered by the second post-operative week. The gelatin-coated pump surface generally was clean without any anticoagulants and free from infection. Embolism, which occurred in two cases, was caused by complications attributable to fungal infection in a Dacron graft and by thrombus formed around a jugular vein catheter. A system with a hybridized microcircuit controller in the interventricular space has been tested successfully in the three most recent cases, with a peak device surface temperature elevation of 6.5° C. Heat effects were confined to the tissues immediately adjacent to the hottest spots. The carbon fiber- reinforced epoxy housing and 60 ml butyl rubber compliance chamber showed good tissue compatibility with a thin, fibrous tissue capsule. The transcutaneous energy transmission system and the internal battery functioned well as designed in the most recent animal implant.

Original languageEnglish (US)
Pages (from-to)M494-M498
JournalASAIO Journal
Volume40
Issue number3
DOIs
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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