Abstract
Synthetic biology is a newly emerged research discipline that focuses on the engineering of novel cellular behaviors and functionalities through the creation of artificial gene circuits. One important class of synthetic circuits currently under active development concerns the programming of bacterial cellular communication and collective population-scale behaviors. Because of the ubiquity of cell-cell interactions within bacterial communities, having an ability of engineering these circuits is vital to programming robust cellular behaviors. Here, we highlight recent advances in communication-based synthetic gene circuits by first discussing natural communication systems and then surveying various functional engineered circuits, including those for population density control, temporal synchronization, spatial organization, and ecosystem formation. We conclude by summarizing recent advances, outlining existing challenges, and discussing potential applications and future opportunities.
| Original language | English (US) |
|---|---|
| Article number | 24 |
| Journal | Bioresources and Bioprocessing |
| Volume | 1 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 1 2014 |
Fingerprint
Keywords
- Bacterial communities
- Cellular communication
- Collective behaviors
- Dynamics
- Gene circuits
- Synthetic biology
ASJC Scopus subject areas
- Biotechnology
- Food Science
- Biomedical Engineering
- Renewable Energy, Sustainability and the Environment
Cite this
Programming the group behaviors of bacterial communities with synthetic cellular communication. / Kong, Wentao; Celik, Venhar; Liao, Chen; Hua, Qiang; Lu, Ting.
In: Bioresources and Bioprocessing, Vol. 1, No. 1, 24, 01.12.2014.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Programming the group behaviors of bacterial communities with synthetic cellular communication
AU - Kong, Wentao
AU - Celik, Venhar
AU - Liao, Chen
AU - Hua, Qiang
AU - Lu, Ting
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Synthetic biology is a newly emerged research discipline that focuses on the engineering of novel cellular behaviors and functionalities through the creation of artificial gene circuits. One important class of synthetic circuits currently under active development concerns the programming of bacterial cellular communication and collective population-scale behaviors. Because of the ubiquity of cell-cell interactions within bacterial communities, having an ability of engineering these circuits is vital to programming robust cellular behaviors. Here, we highlight recent advances in communication-based synthetic gene circuits by first discussing natural communication systems and then surveying various functional engineered circuits, including those for population density control, temporal synchronization, spatial organization, and ecosystem formation. We conclude by summarizing recent advances, outlining existing challenges, and discussing potential applications and future opportunities.
AB - Synthetic biology is a newly emerged research discipline that focuses on the engineering of novel cellular behaviors and functionalities through the creation of artificial gene circuits. One important class of synthetic circuits currently under active development concerns the programming of bacterial cellular communication and collective population-scale behaviors. Because of the ubiquity of cell-cell interactions within bacterial communities, having an ability of engineering these circuits is vital to programming robust cellular behaviors. Here, we highlight recent advances in communication-based synthetic gene circuits by first discussing natural communication systems and then surveying various functional engineered circuits, including those for population density control, temporal synchronization, spatial organization, and ecosystem formation. We conclude by summarizing recent advances, outlining existing challenges, and discussing potential applications and future opportunities.
KW - Bacterial communities
KW - Cellular communication
KW - Collective behaviors
KW - Dynamics
KW - Gene circuits
KW - Synthetic biology
UR - http://www.scopus.com/inward/record.url?scp=85014008203&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85014008203&partnerID=8YFLogxK
U2 - 10.1186/s40643-014-0024-6
DO - 10.1186/s40643-014-0024-6
M3 - Review article
AN - SCOPUS:85014008203
VL - 1
JO - Bioresources and Bioprocessing
JF - Bioresources and Bioprocessing
SN - 2197-4365
IS - 1
M1 - 24
ER -