Progesterone stimulates running wheel activity in adrenalectomized-ovariectomized rats

Babetta L. Marrone; Edward J. Roy; George N. Wade

doi:10.1016/0018-506X(75)90010-0

Progesterone stimulates running wheel activity in adrenalectomized-ovariectomized rats

Babetta L. Marrone, Edward J. Roy, George N. Wade

Research output: Contribution to journal › Article › peer-review

Abstract

Daily treatment with progesterone (5 mg) increased running wheel activity, food intake, and body weight of adrenalectomized-ovariectomized rats. These effects of progesterone are quite similar to those of various corticosteroid treatments in adrenalectomized rats reported previously. In addition, the activity-stimulating action of progesterone is just the opposite of its effect in intact and estradiol-primed ovariectomized rats. These observations are consistent with the hypothesis that the principal role of progesterone in the regulation of body weight is to antagonize the actions of estradiol and that the actions of excessive doses of progesterone in adrenalectomized-ovariectomized rats are simply a by-product of its corticosteroidlike, health-promoting properties.

Original language	English (US)
Pages (from-to)	231-236
Number of pages	6
Journal	Hormones and Behavior
Volume	6
Issue number	3
DOIs	https://doi.org/10.1016/0018-506X(75)90010-0
State	Published - Sep 1975
Externally published	Yes

ASJC Scopus subject areas

Endocrinology
Endocrine and Autonomic Systems
Behavioral Neuroscience

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10.1016/0018-506X(75)90010-0

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title = "Progesterone stimulates running wheel activity in adrenalectomized-ovariectomized rats",

abstract = "Daily treatment with progesterone (5 mg) increased running wheel activity, food intake, and body weight of adrenalectomized-ovariectomized rats. These effects of progesterone are quite similar to those of various corticosteroid treatments in adrenalectomized rats reported previously. In addition, the activity-stimulating action of progesterone is just the opposite of its effect in intact and estradiol-primed ovariectomized rats. These observations are consistent with the hypothesis that the principal role of progesterone in the regulation of body weight is to antagonize the actions of estradiol and that the actions of excessive doses of progesterone in adrenalectomized-ovariectomized rats are simply a by-product of its corticosteroidlike, health-promoting properties.",

author = "Marrone, {Babetta L.} and Roy, {Edward J.} and Wade, {George N.}",

note = "Funding Information: lsupported by grant NS-10873 from the National Institute of Neurological Diseases and Stroke. 2Address reprint requests to Babetta L. Marrone, Institute of Animal Behavior, Rutgers University, 101 WarrenS t., Newark, NJ 07102",

year = "1975",

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doi = "10.1016/0018-506X(75)90010-0",

language = "English (US)",

volume = "6",

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AU - Marrone, Babetta L.

AU - Roy, Edward J.

AU - Wade, George N.

N1 - Funding Information: lsupported by grant NS-10873 from the National Institute of Neurological Diseases and Stroke. 2Address reprint requests to Babetta L. Marrone, Institute of Animal Behavior, Rutgers University, 101 WarrenS t., Newark, NJ 07102

PY - 1975/9

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N2 - Daily treatment with progesterone (5 mg) increased running wheel activity, food intake, and body weight of adrenalectomized-ovariectomized rats. These effects of progesterone are quite similar to those of various corticosteroid treatments in adrenalectomized rats reported previously. In addition, the activity-stimulating action of progesterone is just the opposite of its effect in intact and estradiol-primed ovariectomized rats. These observations are consistent with the hypothesis that the principal role of progesterone in the regulation of body weight is to antagonize the actions of estradiol and that the actions of excessive doses of progesterone in adrenalectomized-ovariectomized rats are simply a by-product of its corticosteroidlike, health-promoting properties.

AB - Daily treatment with progesterone (5 mg) increased running wheel activity, food intake, and body weight of adrenalectomized-ovariectomized rats. These effects of progesterone are quite similar to those of various corticosteroid treatments in adrenalectomized rats reported previously. In addition, the activity-stimulating action of progesterone is just the opposite of its effect in intact and estradiol-primed ovariectomized rats. These observations are consistent with the hypothesis that the principal role of progesterone in the regulation of body weight is to antagonize the actions of estradiol and that the actions of excessive doses of progesterone in adrenalectomized-ovariectomized rats are simply a by-product of its corticosteroidlike, health-promoting properties.

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Progesterone stimulates running wheel activity in adrenalectomized-ovariectomized rats

Abstract

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