Daily treatment with progesterone (5 mg) increased running wheel activity, food intake, and body weight of adrenalectomized-ovariectomized rats. These effects of progesterone are quite similar to those of various corticosteroid treatments in adrenalectomized rats reported previously. In addition, the activity-stimulating action of progesterone is just the opposite of its effect in intact and estradiol-primed ovariectomized rats. These observations are consistent with the hypothesis that the principal role of progesterone in the regulation of body weight is to antagonize the actions of estradiol and that the actions of excessive doses of progesterone in adrenalectomized-ovariectomized rats are simply a by-product of its corticosteroidlike, health-promoting properties.
ASJC Scopus subject areas
- Endocrine and Autonomic Systems
- Behavioral Neuroscience