Progesterone stimulates running wheel activity in adrenalectomized-ovariectomized rats

Babetta L. Marrone, Edward J. Roy, George N. Wade

Research output: Contribution to journalArticlepeer-review


Daily treatment with progesterone (5 mg) increased running wheel activity, food intake, and body weight of adrenalectomized-ovariectomized rats. These effects of progesterone are quite similar to those of various corticosteroid treatments in adrenalectomized rats reported previously. In addition, the activity-stimulating action of progesterone is just the opposite of its effect in intact and estradiol-primed ovariectomized rats. These observations are consistent with the hypothesis that the principal role of progesterone in the regulation of body weight is to antagonize the actions of estradiol and that the actions of excessive doses of progesterone in adrenalectomized-ovariectomized rats are simply a by-product of its corticosteroidlike, health-promoting properties.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalHormones and Behavior
Issue number3
StatePublished - Sep 1975
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience


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