Progesterone, acting through the progesterone receptor isoforms, PGR-A and PGR-B, is one of the most critical regulators of endometrial functions. During early pregnancy, PGR-regulated pathways control uterine epithelial receptivity and stromal differentiation, known as decidualization, which are crucial steps toward the establishment of pregnancy. The PGR isoforms control a substantially large cistrome and transcriptome during decidualization in the mouse and the human. Genetically engineered mouse models have established that several PGR-target genes, such as Ihh, Bmp2, Hoxa10, and Hand2, are essential for implantation and decidualization. This article summarizes literature describing the key PGR-regulated pathways that govern critical uterine functions during the establishment of pregnancy.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Reproduction
Number of pages6
ISBN (Electronic)9780128151457
StatePublished - Jan 1 2018


  • Decidualization
  • Endometrium
  • Epithelium
  • Implantation
  • Progesterone receptor
  • Receptivity
  • Stroma

ASJC Scopus subject areas

  • General Medicine


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