Abstract
Progesterone, acting through the progesterone receptor isoforms, PGR-A and PGR-B, is one of the most critical regulators of endometrial functions. During early pregnancy, PGR-regulated pathways control uterine epithelial receptivity and stromal differentiation, known as decidualization, which are crucial steps toward the establishment of pregnancy. The PGR isoforms control a substantially large cistrome and transcriptome during decidualization in the mouse and the human. Genetically engineered mouse models have established that several PGR-target genes, such as Ihh, Bmp2, Hoxa10, and Hand2, are essential for implantation and decidualization. This article summarizes literature describing the key PGR-regulated pathways that govern critical uterine functions during the establishment of pregnancy.
Original language | English (US) |
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Title of host publication | Encyclopedia of Reproduction |
Publisher | Elsevier |
Pages | 184-189 |
Number of pages | 6 |
ISBN (Electronic) | 9780128151457 |
DOIs | |
State | Published - Jan 1 2018 |
Keywords
- Decidualization
- Endometrium
- Epithelium
- Implantation
- Progesterone receptor
- Receptivity
- Stroma
ASJC Scopus subject areas
- General Medicine