Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation

Chan Jin Park, Po Ching Lin, Sherry Zhou, Radwa Barakat, Shah Tauseef Bashir, Jeong Moon Choi, Joseph A. Cacioppo, Oliver R. Oakley, Diane M. Duffy, John P. Lydon, Che Myong J. Ko

Research output: Contribution to journalArticle

Abstract

A preovulatory LH surge induces the expression of PGR and the production of PGE2, a proinflammatory prostaglandin, in preovulatory granulosa cells. Park et al. show that PGR then suppresses PGE2 synthesis by decreasing the expression of PTGS2. Such PGR-driven termination temporarily confines ovulatory inflammation within a short period.

Original languageEnglish (US)
Article number107496
JournalCell Reports
Volume31
Issue number2
DOIs
StatePublished - Apr 14 2020

Keywords

  • PGR
  • PTGS2
  • granulosa cells
  • inflammation
  • ovulation
  • prostaglandin E2
  • single-cell RNA sequencing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation'. Together they form a unique fingerprint.

  • Cite this

    Park, C. J., Lin, P. C., Zhou, S., Barakat, R., Bashir, S. T., Choi, J. M., Cacioppo, J. A., Oakley, O. R., Duffy, D. M., Lydon, J. P., & Ko, C. M. J. (2020). Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation. Cell Reports, 31(2), [107496]. https://doi.org/10.1016/j.celrep.2020.03.060