Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation

Chan Jin Park; Po Ching Lin; Sherry Zhou; Radwa Barakat; Shah Tauseef Bashir; Jeong Moon Choi; Joseph A. Cacioppo; Oliver R. Oakley; Diane M. Duffy; John P. Lydon; Che Myong J. Ko

doi:10.1016/j.celrep.2020.03.060

Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation

Chan Jin Park, Po Ching Lin, Sherry Zhou, Radwa Barakat, Shah Tauseef Bashir, Jeong Moon Choi, Joseph A. Cacioppo, Oliver R. Oakley, Diane M. Duffy, John P. Lydon, Che Myong J. Ko

Research output: Contribution to journal › Article

Abstract

A preovulatory LH surge induces the expression of PGR and the production of PGE2, a proinflammatory prostaglandin, in preovulatory granulosa cells. Park et al. show that PGR then suppresses PGE2 synthesis by decreasing the expression of PTGS2. Such PGR-driven termination temporarily confines ovulatory inflammation within a short period.

Original language	English (US)
Article number	107496
Journal	Cell Reports
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2020.03.060
State	Published - Apr 14 2020

Keywords

PGR
PTGS2
granulosa cells
inflammation
ovulation
prostaglandin E2
single-cell RNA sequencing

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1016/j.celrep.2020.03.060

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Park, C. J., Lin, P. C., Zhou, S., Barakat, R., Bashir, S. T., Choi, J. M., Cacioppo, J. A., Oakley, O. R., Duffy, D. M., Lydon, J. P., & Ko, C. M. J. (2020). Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation. Cell Reports, 31(2), [107496]. https://doi.org/10.1016/j.celrep.2020.03.060

Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation. / Park, Chan Jin; Lin, Po Ching; Zhou, Sherry; Barakat, Radwa; Bashir, Shah Tauseef; Choi, Jeong Moon; Cacioppo, Joseph A.; Oakley, Oliver R.; Duffy, Diane M.; Lydon, John P.; Ko, Che Myong J.

In: Cell Reports, Vol. 31, No. 2, 107496, 14.04.2020.

Research output: Contribution to journal › Article

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