A preovulatory LH surge induces the expression of PGR and the production of PGE2, a proinflammatory prostaglandin, in preovulatory granulosa cells. Park et al. show that PGR then suppresses PGE2 synthesis by decreasing the expression of PTGS2. Such PGR-driven termination temporarily confines ovulatory inflammation within a short period.
- granulosa cells
- prostaglandin E2
- single-cell RNA sequencing
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)