@article{b3b06aeeefd84ecc9e1fd50a867412f5,
title = "Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation",
abstract = "A preovulatory LH surge induces the expression of PGR and the production of PGE2, a proinflammatory prostaglandin, in preovulatory granulosa cells. Park et al. show that PGR then suppresses PGE2 synthesis by decreasing the expression of PTGS2. Such PGR-driven termination temporarily confines ovulatory inflammation within a short period.",
keywords = "PGR, PTGS2, granulosa cells, inflammation, ovulation, prostaglandin E2, single-cell RNA sequencing",
author = "Park, {Chan Jin} and Lin, {Po Ching} and Sherry Zhou and Radwa Barakat and Bashir, {Shah Tauseef} and Choi, {Jeong Moon} and Cacioppo, {Joseph A.} and Oakley, {Oliver R.} and Duffy, {Diane M.} and Lydon, {John P.} and Ko, {Che Myong J.}",
note = "Funding Information: We thank Dr. C.L. Wright (Roy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign), Dr. C.J. Fields (HPCBio, University of Illinois at Urbana-Champaign), Dr. J. Drnevich (HPCBio), and Dr. M. Tseng (HPCBio) for their assistance in performing single-cell RNA sequencing and analyzing data. This work was supported by grants from the National Institutes of Health (NIH) ( HD071875 and HD094296 to C.J.K.; HD042311 to J.P.L.). Funding Information: We thank Dr. C.L. Wright (Roy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign), Dr. C.J. Fields (HPCBio, University of Illinois at Urbana-Champaign), Dr. J. Drnevich (HPCBio), and Dr. M. Tseng (HPCBio) for their assistance in performing single-cell RNA sequencing and analyzing data. This work was supported by grants from the National Institutes of Health (NIH) (HD071875 and HD094296 to C.J.K.; HD042311 to J.P.L.). C.J.P. and C.J.K. designed and performed experiments, analyzed and interpreted data, and wrote the manuscript. P.-C.L. S.Z. and J.M.C. designed and performed experiments and analyzed data. R.B. S.T.B. J.A.C. and O.R.O. designed experiments and interpreted data. J.P.L. provided critical transgenic mice. D.M.D. interpreted data and edited the manuscript. All authors edited and approved the final manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = apr,
day = "14",
doi = "10.1016/j.celrep.2020.03.060",
language = "English (US)",
volume = "31",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "2",
}