Abstract
A preovulatory LH surge induces the expression of PGR and the production of PGE2, a proinflammatory prostaglandin, in preovulatory granulosa cells. Park et al. show that PGR then suppresses PGE2 synthesis by decreasing the expression of PTGS2. Such PGR-driven termination temporarily confines ovulatory inflammation within a short period.
Original language | English (US) |
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Article number | 107496 |
Journal | Cell Reports |
Volume | 31 |
Issue number | 2 |
DOIs | |
State | Published - Apr 14 2020 |
Keywords
- PGR
- PTGS2
- granulosa cells
- inflammation
- ovulation
- prostaglandin E2
- single-cell RNA sequencing
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology