Abstract
Adipic acid is one of the most important industrial dicarboxylic acids and is used mainly as a precursor to nylon-6,6. Currently, commercial adipic acid is produced primarily from benzene by a chemical route that is associated with environmental, health, and safety concerns. Herein, we report a new process to produce adipic acid from an inexpensive renewable feedstock, sugar beet residue by combining an engineered Escherichia coli strain and Re-based chemical catalysts. The engineered E.coli converted d-galacturonic acid to mucic acid, which was precipitated easily with acid, and the mucic acid was further converted to adipic acid by a deoxydehydration reaction catalyzed by an oxorhenium complex followed by a Pt/C-catalyzed hydrogenation reaction under mild conditions. A high selectivity to the free acid products was achieved by tuning the acidity of the Re-based catalysts. Finally, adipic acid was produced directly from sugar beet residue that was hydrolyzed enzymatically with engineered E.coli and two chemical catalysts in a yield of 8.4 %, which signifies a new route for the production of adipic acid.
Original language | English (US) |
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Pages (from-to) | 1500-1506 |
Number of pages | 7 |
Journal | ChemCatChem |
Volume | 8 |
Issue number | 8 |
DOIs | |
State | Published - Apr 20 2016 |
Keywords
- biocatalysis
- biomass
- gene technology
- homogeneous catalysis
- rhenium
ASJC Scopus subject areas
- Catalysis
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry