Procion yellow fluorescent microscopy: a new method of studying arterial and venous pathology

R B Berlin, P Farnsworth, B Groth-Vasselli, J A Kuo

Research output: Contribution to journalArticlepeer-review

Abstract

A new means of studying vessel wall pathology is presented. This technique utilizes Procion yellow, a vital fluorescent dye, to stain and delineate the connective elements, matrix, and elastic tissue within the arterial wall. In addition, penetration of the dye into cells provides evidence of membrane pathology. A canine model was used, and clamped segments of femoral artery were stained and examined. The appreciation of this approach for the examination of the vessel wall shows alterations in tissue elements that have not been reported previously. This technique makes possible a unique means of studying connective tissue elements as well as membrane integrity.

Original languageEnglish (US)
Pages (from-to)893-898
Number of pages6
JournalAngiology
Volume43
Issue number11
DOIs
StatePublished - Nov 1992
Externally publishedYes

Keywords

  • Animals
  • Blood Vessels/pathology
  • Constriction
  • Dogs
  • Femoral Artery/pathology
  • Fluorescent Dyes
  • Microscopy, Fluorescence
  • Triazines

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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