Procaspase 3 activation by combination therapy

Paul J Hergenrother (Inventor), Rachel C Botham (Inventor), Timothy M Fan (Inventor), Mark John Gilbert (Inventor), Michael Kevin Handley (Inventor), Howard S Roth (Inventor), Theodore M. Tarasow (Inventor)

Research output: Patent


The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.
Original languageEnglish (US)
U.S. patent number10085977
StatePublished - Oct 2 2018


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