Probiotics in Milk as Functional Food: Characterization and Nutraceutical Properties of Extracted Phenolics and Peptides from Fermented Skimmed Milk Inoculated with Royal Jelly

Muhammad H. Alu'datt, Taha Rababah, Mohammad M. Obaidat, Khalil Ereifej, Mohammad N. Alhamad, Nizar Mhaidat, Juan E. Andrade, Ayman Johargy, Wafa Ayadi

Research output: Contribution to journalArticle

Abstract

This study evaluated the biological properties of milk fermented with Lactobacillus acidophilus with and without several amounts of royal jelly including: total viable count, pH, titratable acidity, antioxidant activity and inhibitory activities of angiotensin 1-converting enzyme (ACE), α-amylase, and growth of colorectal (SW480) and skin (MV3) cancer cell lines. The bound phenolic extract after acid hydrolysis had better biological properties. The antioxidant activities increased after 4h of fermentation time in skimmed milk fortified with royal jelly. Contents of aromatic compounds decreased along fermentation time in skimmed milk with royal jelly. The in vitro inhibitory activities against skin and colorectal cancer growth of fermented skimmed milk were not dependent on fermentation time and concentration of royal jelly. Results revealed the accumulation of hydrolytic bioactive peptides with inhibitory activity of ACE at 24h. Practical Applications: Inoculated skimmed milk with different ratios of royal jelly has potential application to manage chronic human diseases including hyperglycemia (type 2 diabetes), hypertension, and breast and skin cancers.

Original languageEnglish (US)
Pages (from-to)509-522
Number of pages14
JournalJournal of Food Safety
Volume35
Issue number4
DOIs
StatePublished - Nov 2015

ASJC Scopus subject areas

  • Parasitology
  • Food Science
  • Microbiology

Fingerprint Dive into the research topics of 'Probiotics in Milk as Functional Food: Characterization and Nutraceutical Properties of Extracted Phenolics and Peptides from Fermented Skimmed Milk Inoculated with Royal Jelly'. Together they form a unique fingerprint.

  • Cite this