Probing DNA structure with nanoparticles.

Rahina Mahtab, Catherine J. Murphy

Research output: Contribution to journalArticle

Abstract

Semiconductor nanoparticles, also known as quantum dots, are receiving increasing attention for their biological applications. These nanomaterials are photoluminescent and are being developed both as dyes and as sensors. Here we describe our "sensor" use of quantum dots to detect different intrinsic DNA structures. Structural polymorphism in DNA may serve as a biological signal in vivo, highlighting the need for recognition of DNA structure in addition to DNA sequence in biotechnology assays.

Original languageEnglish (US)
Pages (from-to)179-190
Number of pages12
JournalMethods in molecular biology (Clifton, N.J.)
Volume303
DOIs
StatePublished - 2005
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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