Research output per year
Research output per year
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Pharmacodynamics (PD) and toxicodynamics relate doses of an agent to the characteristics, quantity, and time course of its biological effect. Together with pharmacokinetic (PK) considerations, the mechanism of action is a key determinant of effect and toxicity. This chapter reviews the terminology, theory, and graphical representation of receptor occupancy by a drug/toxin (Scatchard, sigmoidal log-dose response), and then compares them with graded dose-effect relationships. A brief review of signal transduction mechanisms introduces a more detailed discussion of receptor agonism and antagonism using the reversible two-state receptor theory. Dynamic receptor phenomena leading to hyporeactivity and hyperreactivity are explained through signal transduction and other physiological mechanisms. Finally, methods of estimating drug selectivity and safety (therapeutic index) are summarized. The increasing importance of nonmonotonic dose-effect curves, such those characterized by endocrine disruption, is highlighted. Finally, principles of PK/PD modeling are outlined as a way of improving clinical trial design.
Original language | English (US) |
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Title of host publication | Fundamentals of Toxicologic Pathology |
Editors | Matthew A Wallig, Wanda M Haschek, Colin G Rousseaux, Brad Bolon |
Publisher | Academic Press |
Pages | 47-58 |
Number of pages | 12 |
Edition | 3 |
ISBN (Electronic) | 9780128098424 |
ISBN (Print) | 9780128098417 |
DOIs | |
State | Published - 2018 |
Research output: Book/Report/Conference proceeding › Book