Primary epitheliotropic intestinal T-cell lymphoma in a horse

Marie E. Pinkerton, Keith L. Bailey, Kathy K. Thomas, Thomas E. Goetz, Victor E. Valli

Research output: Contribution to journalArticlepeer-review


A 17-year-old Quarterhorse gelding with a clinical diagnosis of protein-losing enteropathy was submitted for necropsy following a 4-5-month duration of weight loss, decreased appetite, and hypoproteinemia. Gross findings included multiple 1-2-cm diameter ulcers on the luminal surfaces of the duodenum and ileum. Histologic examination revealed individual large, round cells infiltrating much of the mucosal epithelium of the duodenum, jejunum, ileum, and colon in addition to multifocal areas of ulceration. Similar round cells infiltrated Brunner's glands and expanded the submucosa beneath the foci of ulceration. Immunohistochemical staining indicated the round cell population was of T-lymphocyte origin. Several features of this equine neoplasm bear similarities to enteropathy-associated T-cell lymphoma in humans.

Original languageEnglish (US)
Pages (from-to)150-152
Number of pages3
JournalJournal of Veterinary Diagnostic Investigation
Issue number2
StatePublished - Mar 2002

ASJC Scopus subject areas

  • General Veterinary


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