Abstract
The efficacy of a highly activated charcoal in preventing the morphologic effects of T-2 toxin was examined in female rats. T-2 toxin at 25 mg/kg (6×LD50) was given orally to all rats. Half the rats also received the charcoal, at a dose of 9 ml/kg and a concentration of 104 mg/ ml, while the other half received water. A charcoal-treated rat (T-2 toxin + charcoal) was killed at the time of death of each positive control animal (T-2 toxin alone). Severe necrosis was seen in the spleen, thymus, stomach, small intestine, liver and adrenal glands of the positive controls (T-2 toxin alone). Lesions were absent or minimal in the paired charcoal-treated rats (T-2 toxin + charcoal).
Original language | English (US) |
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Pages (from-to) | 251-253 |
Number of pages | 3 |
Journal | Archives of Toxicology |
Volume | 64 |
Issue number | 3 |
DOIs | |
State | Published - Apr 1990 |
Keywords
- Charcoal
- Pathology
- Rats
- T-2 toxin
- Trichothecenes
ASJC Scopus subject areas
- Toxicology
- Health, Toxicology and Mutagenesis