Prevention of T-2 toxin-induced morphologic effects in the rat by highly activated charcoal

Paula M. Bratich, William B. Buck, Wanda M. Haschek

Research output: Contribution to journalArticlepeer-review

Abstract

The efficacy of a highly activated charcoal in preventing the morphologic effects of T-2 toxin was examined in female rats. T-2 toxin at 25 mg/kg (6×LD50) was given orally to all rats. Half the rats also received the charcoal, at a dose of 9 ml/kg and a concentration of 104 mg/ ml, while the other half received water. A charcoal-treated rat (T-2 toxin + charcoal) was killed at the time of death of each positive control animal (T-2 toxin alone). Severe necrosis was seen in the spleen, thymus, stomach, small intestine, liver and adrenal glands of the positive controls (T-2 toxin alone). Lesions were absent or minimal in the paired charcoal-treated rats (T-2 toxin + charcoal).

Original languageEnglish (US)
Pages (from-to)251-253
Number of pages3
JournalArchives of Toxicology
Volume64
Issue number3
DOIs
StatePublished - Apr 1 1990

Keywords

  • Charcoal
  • Pathology
  • Rats
  • T-2 toxin
  • Trichothecenes

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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