Preventing an Antigenically Disruptive Mutation in Egg-Based H3N2 Seasonal Influenza Vaccines by Mutational Incompatibility

Nicholas C. Wu, Huibin Lv, Andrew J. Thompson, Douglas C. Wu, Wilson W.S. Ng, Rameshwar U. Kadam, Chih Wei Lin, Corwin M. Nycholat, Ryan McBride, Weiwen Liang, James C. Paulson, Chris K.P. Mok, Ian A. Wilson

Research output: Contribution to journalArticlepeer-review

Abstract

Wu et al. characterize the incompatibility between two major egg-adaptive mutations in human H3N2 virus hemagglutinin, G186V and L194P, which confer either minimal or significant antigenic change, respectively. This study suggests that the antigenically disruptive mutation L194P that occurs during egg-based influenza vaccine production can be prevented by mutational incompatibility.

Original languageEnglish (US)
Pages (from-to)836-844.e5
JournalCell Host and Microbe
Volume25
Issue number6
DOIs
StatePublished - Jun 12 2019
Externally publishedYes

Keywords

  • antigenicity
  • egg-adaptive mutation
  • epistasis
  • hemagglutinin
  • influenza virus
  • receptor binding
  • vaccine

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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