TY - JOUR
T1 - Prevalence of urogenital carcinoma in stranded California sea lions (Zalophus californianus) from 2005-15
AU - Deming, Alissa C.
AU - Colegrove, Kathleen M.
AU - Duignan, Padraig J.
AU - Hall, Ailsa J.
AU - Wellehan, James F.X.
AU - Gulland, Frances M.D.
N1 - Publisher Copyright:
© Wildlife Disease Association 2018.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Urogenital carcinoma is common in wild California sea lions (Zalophus californianus) along the west coast of the US. From 1979 to 1994, this cancer was observed in 18% (66/370) of necropsied subadult and adult sea lions at The Marine Mammal Center in Sausalito, California. A retrospective review of records from 1 January 2005 to 31 December 2015 was performed to characterize prevalence and characteristics of cancer over this decade. Fourteen percent (263/ 1917) of necropsied sea lions had cancer, of which 90% (237/263) were urogenital carcinoma. The prevalence of urogenital carcinoma was significantly higher in adults compared to juveniles and subadults. Advanced-stage disease with metastases was identified histologically in 78% (182/232) of cases and was the cause of death in 95% (172/ 182) of these cases. Metastases were most common in lung and lymph nodes, and hydronephrosis, secondary to ureter obstruction by metastases, was identified in 62% (114/185) of animals with advanced disease. No significant temporal change in prevalence was detected over the decade, and this highly aggressive, fatal cancer remains common in stranded California sea lions.
AB - Urogenital carcinoma is common in wild California sea lions (Zalophus californianus) along the west coast of the US. From 1979 to 1994, this cancer was observed in 18% (66/370) of necropsied subadult and adult sea lions at The Marine Mammal Center in Sausalito, California. A retrospective review of records from 1 January 2005 to 31 December 2015 was performed to characterize prevalence and characteristics of cancer over this decade. Fourteen percent (263/ 1917) of necropsied sea lions had cancer, of which 90% (237/263) were urogenital carcinoma. The prevalence of urogenital carcinoma was significantly higher in adults compared to juveniles and subadults. Advanced-stage disease with metastases was identified histologically in 78% (182/232) of cases and was the cause of death in 95% (172/ 182) of these cases. Metastases were most common in lung and lymph nodes, and hydronephrosis, secondary to ureter obstruction by metastases, was identified in 62% (114/185) of animals with advanced disease. No significant temporal change in prevalence was detected over the decade, and this highly aggressive, fatal cancer remains common in stranded California sea lions.
KW - California sea lions
KW - Cancer
KW - Stranding
KW - Urogenital carcinoma
KW - Zalophus californianus
UR - http://www.scopus.com/inward/record.url?scp=85049673790&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049673790&partnerID=8YFLogxK
U2 - 10.7589/2017-08-208
DO - 10.7589/2017-08-208
M3 - Article
C2 - 29498901
AN - SCOPUS:85049673790
SN - 0090-3558
VL - 54
SP - 581
EP - 586
JO - Journal of wildlife diseases
JF - Journal of wildlife diseases
IS - 3
ER -