TY - JOUR
T1 - Pretreatment dietary patterns are associated with the presence of nutrition impact symptoms 1 year after diagnosis in patients with head and neck cancer
AU - Crowder, Sylvia L.
AU - Sarma, Kalika P.
AU - Mondul, Alison M.
AU - Chen, Yi Tang
AU - Li, Zonggui
AU - Yanina Pepino, M.
AU - Zarins, Katie R.
AU - Wolf, Gregory T.
AU - Rozek, Laura S.
AU - Arthur, Anna E.
N1 - Funding Information:
K.R. Zarins reports receiving a commercial research grant from Brooklyn ImmunoTherapeutics. No potential conflicts of interest were disclosed by the other authors.
Funding Information:
The authors thank the patients, clinicians, and principal investigators of the individual projects at the UM Head and Neck SPORE program who provided access to the longitudinal clinical database and were responsible for the recruitment, treatment, and follow-up of patients included in this article. These investigators included Avraham Eisbruch, Theodore Lawrence, Mark Prince, Jeffrey Terrell, Shaomeng Wang, and Frank Worden. NIH/NCI P50CA097248 was awarded to G.T. Wolf. USDA National Institute of Food and Agriculture, Hatch project 1011487 was awarded to A.E. Arthur. S.L. Crowder was supported by a Carle-Illinois Cancer Scholars for Translational and Applied Research Fellowship and an Academy of Nutrition and Dietetics Colgate Palmolive Fellowship in Nutrition and Oral Health.
PY - 2019
Y1 - 2019
N2 - Background: Dietary inflammatory potential could impact the presence and severity of chronic adverse treatment effects among patients with head and neck cancer. The objective of this study was to determine whether pretreatment dietary patterns are associated with nutrition impact symptoms (NIS) as self-reported 1 year after diagnosis. Methods: This was a longitudinal study of 336 patients with newly diagnosed head and neck cancer enrolled in the University of Michigan Head and Neck Specialized Program of Research Excellence. Principal component analysis was utilized to derive pretreatment dietary patterns from food frequency questionnaire data. Burden of seven NIS was self-reported 1 year after diagnosis. Associations between pretreatment dietary patterns and individual symptoms and a composite NIS summary score were examined with multivariable logistic regression models. Results: The two dietary patterns that emerged were prudent and Western. After adjusting for age, smoking status, body mass index, tumor site, cancer stage, calories, and human papillomavirus status, significant inverse associations were observed between the prudent pattern and difficulty chewing [OR 0.44; 95% confidence interval (CI), 0.21–0.93; P ¼ 0.03], dysphagia of liquids (OR 0.38; 95% CI, 0.18–0.79; P ¼ 0.009), dysphagia of solid foods (OR 0.46; 95% CI, 0.22–0.96; P ¼ 0.03), mucositis (OR 0.48; 95% CI, 0.24–0.96; P ¼ 0.03), and the NIS summary score (OR 0.45; 95% CI, 0.22–0.94; P ¼ 0.03). No significant associations were observed between the Western pattern and NIS. Conclusions: Consumption of a prudent diet before treatment may help reduce the risk of chronic NIS burden among head and neck cancer survivors. Impact: Dietary interventions are needed to test whether consumption of a prudent dietary pattern before and during head and neck cancer treatment results in reduced NIS burden.
AB - Background: Dietary inflammatory potential could impact the presence and severity of chronic adverse treatment effects among patients with head and neck cancer. The objective of this study was to determine whether pretreatment dietary patterns are associated with nutrition impact symptoms (NIS) as self-reported 1 year after diagnosis. Methods: This was a longitudinal study of 336 patients with newly diagnosed head and neck cancer enrolled in the University of Michigan Head and Neck Specialized Program of Research Excellence. Principal component analysis was utilized to derive pretreatment dietary patterns from food frequency questionnaire data. Burden of seven NIS was self-reported 1 year after diagnosis. Associations between pretreatment dietary patterns and individual symptoms and a composite NIS summary score were examined with multivariable logistic regression models. Results: The two dietary patterns that emerged were prudent and Western. After adjusting for age, smoking status, body mass index, tumor site, cancer stage, calories, and human papillomavirus status, significant inverse associations were observed between the prudent pattern and difficulty chewing [OR 0.44; 95% confidence interval (CI), 0.21–0.93; P ¼ 0.03], dysphagia of liquids (OR 0.38; 95% CI, 0.18–0.79; P ¼ 0.009), dysphagia of solid foods (OR 0.46; 95% CI, 0.22–0.96; P ¼ 0.03), mucositis (OR 0.48; 95% CI, 0.24–0.96; P ¼ 0.03), and the NIS summary score (OR 0.45; 95% CI, 0.22–0.94; P ¼ 0.03). No significant associations were observed between the Western pattern and NIS. Conclusions: Consumption of a prudent diet before treatment may help reduce the risk of chronic NIS burden among head and neck cancer survivors. Impact: Dietary interventions are needed to test whether consumption of a prudent dietary pattern before and during head and neck cancer treatment results in reduced NIS burden.
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U2 - 10.1158/1055-9965.EPI-19-0128
DO - 10.1158/1055-9965.EPI-19-0128
M3 - Article
C2 - 31315911
AN - SCOPUS:85072849172
VL - 28
SP - 1652
EP - 1659
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
SN - 1055-9965
IS - 10
ER -