Abstract
Background: Dietary inflammatory potential could impact the presence and severity of chronic adverse treatment effects among patients with head and neck cancer. The objective of this study was to determine whether pretreatment dietary patterns are associated with nutrition impact symptoms (NIS) as self-reported 1 year after diagnosis. Methods: This was a longitudinal study of 336 patients with newly diagnosed head and neck cancer enrolled in the University of Michigan Head and Neck Specialized Program of Research Excellence. Principal component analysis was utilized to derive pretreatment dietary patterns from food frequency questionnaire data. Burden of seven NIS was self-reported 1 year after diagnosis. Associations between pretreatment dietary patterns and individual symptoms and a composite NIS summary score were examined with multivariable logistic regression models. Results: The two dietary patterns that emerged were prudent and Western. After adjusting for age, smoking status, body mass index, tumor site, cancer stage, calories, and human papillomavirus status, significant inverse associations were observed between the prudent pattern and difficulty chewing [OR 0.44; 95% confidence interval (CI), 0.21–0.93; P ¼ 0.03], dysphagia of liquids (OR 0.38; 95% CI, 0.18–0.79; P ¼ 0.009), dysphagia of solid foods (OR 0.46; 95% CI, 0.22–0.96; P ¼ 0.03), mucositis (OR 0.48; 95% CI, 0.24–0.96; P ¼ 0.03), and the NIS summary score (OR 0.45; 95% CI, 0.22–0.94; P ¼ 0.03). No significant associations were observed between the Western pattern and NIS. Conclusions: Consumption of a prudent diet before treatment may help reduce the risk of chronic NIS burden among head and neck cancer survivors. Impact: Dietary interventions are needed to test whether consumption of a prudent dietary pattern before and during head and neck cancer treatment results in reduced NIS burden.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1652-1659 |
| Number of pages | 8 |
| Journal | Cancer Epidemiology Biomarkers and Prevention |
| Volume | 28 |
| Issue number | 10 |
| DOIs | |
| State | Published - Jan 1 2019 |
Fingerprint
ASJC Scopus subject areas
- Epidemiology
- Oncology
Cite this
Pretreatment dietary patterns are associated with the presence of nutrition impact symptoms 1 year after diagnosis in patients with head and neck cancer. / Crowder, Sylvia L.; Sarma, Kalika P.; Mondul, Alison M.; Chen, Yi Tang; Li, Zonggui; Yanina Pepino, M.; Zarins, Katie R.; Wolf, Gregory T.; Rozek, Laura S.; Arthur, Anna E.
In: Cancer Epidemiology Biomarkers and Prevention, Vol. 28, No. 10, 01.01.2019, p. 1652-1659.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pretreatment dietary patterns are associated with the presence of nutrition impact symptoms 1 year after diagnosis in patients with head and neck cancer
AU - Crowder, Sylvia L.
AU - Sarma, Kalika P.
AU - Mondul, Alison M.
AU - Chen, Yi Tang
AU - Li, Zonggui
AU - Yanina Pepino, M.
AU - Zarins, Katie R.
AU - Wolf, Gregory T.
AU - Rozek, Laura S.
AU - Arthur, Anna E.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: Dietary inflammatory potential could impact the presence and severity of chronic adverse treatment effects among patients with head and neck cancer. The objective of this study was to determine whether pretreatment dietary patterns are associated with nutrition impact symptoms (NIS) as self-reported 1 year after diagnosis. Methods: This was a longitudinal study of 336 patients with newly diagnosed head and neck cancer enrolled in the University of Michigan Head and Neck Specialized Program of Research Excellence. Principal component analysis was utilized to derive pretreatment dietary patterns from food frequency questionnaire data. Burden of seven NIS was self-reported 1 year after diagnosis. Associations between pretreatment dietary patterns and individual symptoms and a composite NIS summary score were examined with multivariable logistic regression models. Results: The two dietary patterns that emerged were prudent and Western. After adjusting for age, smoking status, body mass index, tumor site, cancer stage, calories, and human papillomavirus status, significant inverse associations were observed between the prudent pattern and difficulty chewing [OR 0.44; 95% confidence interval (CI), 0.21–0.93; P ¼ 0.03], dysphagia of liquids (OR 0.38; 95% CI, 0.18–0.79; P ¼ 0.009), dysphagia of solid foods (OR 0.46; 95% CI, 0.22–0.96; P ¼ 0.03), mucositis (OR 0.48; 95% CI, 0.24–0.96; P ¼ 0.03), and the NIS summary score (OR 0.45; 95% CI, 0.22–0.94; P ¼ 0.03). No significant associations were observed between the Western pattern and NIS. Conclusions: Consumption of a prudent diet before treatment may help reduce the risk of chronic NIS burden among head and neck cancer survivors. Impact: Dietary interventions are needed to test whether consumption of a prudent dietary pattern before and during head and neck cancer treatment results in reduced NIS burden.
AB - Background: Dietary inflammatory potential could impact the presence and severity of chronic adverse treatment effects among patients with head and neck cancer. The objective of this study was to determine whether pretreatment dietary patterns are associated with nutrition impact symptoms (NIS) as self-reported 1 year after diagnosis. Methods: This was a longitudinal study of 336 patients with newly diagnosed head and neck cancer enrolled in the University of Michigan Head and Neck Specialized Program of Research Excellence. Principal component analysis was utilized to derive pretreatment dietary patterns from food frequency questionnaire data. Burden of seven NIS was self-reported 1 year after diagnosis. Associations between pretreatment dietary patterns and individual symptoms and a composite NIS summary score were examined with multivariable logistic regression models. Results: The two dietary patterns that emerged were prudent and Western. After adjusting for age, smoking status, body mass index, tumor site, cancer stage, calories, and human papillomavirus status, significant inverse associations were observed between the prudent pattern and difficulty chewing [OR 0.44; 95% confidence interval (CI), 0.21–0.93; P ¼ 0.03], dysphagia of liquids (OR 0.38; 95% CI, 0.18–0.79; P ¼ 0.009), dysphagia of solid foods (OR 0.46; 95% CI, 0.22–0.96; P ¼ 0.03), mucositis (OR 0.48; 95% CI, 0.24–0.96; P ¼ 0.03), and the NIS summary score (OR 0.45; 95% CI, 0.22–0.94; P ¼ 0.03). No significant associations were observed between the Western pattern and NIS. Conclusions: Consumption of a prudent diet before treatment may help reduce the risk of chronic NIS burden among head and neck cancer survivors. Impact: Dietary interventions are needed to test whether consumption of a prudent dietary pattern before and during head and neck cancer treatment results in reduced NIS burden.
UR - http://www.scopus.com/inward/record.url?scp=85072849172&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072849172&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-19-0128
DO - 10.1158/1055-9965.EPI-19-0128
M3 - Article
C2 - 31315911
AN - SCOPUS:85072849172
VL - 28
SP - 1652
EP - 1659
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
SN - 1055-9965
IS - 10
ER -